1 vaccine to prevent 12 cancers? Don't make fun of it!

According to media reports, Hong Kong MDX Medical Group released the "DCV cancer vaccine", 98,000 yuan injection, can prevent more than 12 types of cancer including prostate cancer, breast cancer, lung cancer and so onand this good thing? Science and Technology Daily reporter immediately connected with the China Anti-Cancer Association science and technology propaganda minister, the capital medical university Xuanwu Hospital professor Shi Xiuyi, to listen to what he saidIspseudoscience? Try these three "mirrors""what cancer can cure?" From this ad word, it can basically be judged to be pseudo-science"Shisuyi told Science and Technology Daily reporter, not to mention, in terms of lung cancer alone, there are small cell lung cancer and non-small cell lung cancer; Preventing lung cancer alone is unlikely, let alone 12 cancersthis characteristic of malignant tumors is known academically as "heterogeneity" and can be generally understood that even if classified as the same tumor, it can be completely differentAcademic articles have shown that heterogeneity is divided into two types: one is that at different times when the tumor occurs, the same patient's tumor cells have different genetic mutations, and the other is that different patients have the same tumor, but that "same" may not be the same, just the phenotype is the same, does not represent the same genotypeZhang Xuemin, a member of the Chinese Academy of Sciences in, had previously explained "heterogeneity" in a very graphic analogy at an academic seminarHe said: The human genome is like taking a disk, falling into the ground, falling a million times without two fragments is the same, no two tumor patients mutation is the sameThe human body has 3 billion base pairs, and changing tens of millions may not develop tumorsThe main problem with treating tumors is finding which is the driving mutation that can be targetedScientists are now using big data to find the most critical driver genes (which can be understood as core components), and thousands of tumor-driven genes are currently found based on clinical data and ratiosit can be seen that, only by the "DCV cancer vaccine" product description mentioned in the case, control of the broad spectrum WT1 gene can be prevented (first assuming that the injected substance can regulate the gene) is currently impossible, the so-called "universal gene" is purely falsetherefore, "all-encompassing, cure a hundred diseases" is the first "mirror", especially for the occurrence of complex mechanisms of malignant tumors, it is not possible to "one enemy ten"", "this kind of pseudoscience also has a characteristic, there is no specific research institutions and research events If it is a true thing, there should be specific scientific research projects and scientific research data, should be at the international or domestic cancer conference results to be displayed "If it is clear that the work of a research institute or scientific research team at a certain University in the United States has been conducted and a series of experimental studies have been conducted, then other teams of scientists should be able to validate the study or present its findings and data at the ASCO or the National Oncology Conference CSCO meeting." and the Hong Kong MDX Medical Group released "DCV Cancer Vaccine" does not disclose any clinical trial data, how the relevant clinical validation is advanced, the effectiveness of Phase III clinical studies, whether there are related papers published in academic journals, which scientists and research team participated in the research To put it bluntly, the result is like a result of nothing, can not be "traced" "produced out of thin air, can not trace the source" is the second side of the "mirror", "commercial manipulation, profit speculation" is the third side of the "mirror." " the emergence of fake news, though out of thin air, must be driven by huge economic benefits Research and innovation of new anti-tumor drugs requires significant funding, especially in the clinical validation phase, which requires hundreds of millions of dollars, he said at this time the concept of speculation, to raise the stock price, into the capital and other methods have become a lot of capital players, and fake news has become their "play around" capital market one of the springboard Sales performance and followers, as long as the head, this wave of operations may attract investment, become a so-called "model" of commercial manipulation As some media analysis, its commercial essence is "cutting leeks" don't let pseudo-science "fry" the tumor vaccine
this is a false rumor about the tumor vaccine, but "tumor vaccine" is a real new type of biotechnology in recent years familiar include: cervical cancer vaccine, hepatitis B vaccine and so on "In principle, the principle of preventive tumor vaccine is to prevent microbial infection and induce tumors." For example, cervical cancer vaccine is to prevent polymatoma virus, hepatitis B vaccine is to prevent liver cancer, prevent EB virus, prevent nasopharyngeal cancer, prevention of Helicobacter pylori, prevention of stomach cancer Li Zhongming, editor-in-chief of the "Modern New Vaccine" (first edition), who has worked on the FDA's review, explained to Science Daily that the current preventive cancer vaccine must be related to microorganisms, and only therapeutic vaccines are targeted at tumors draw the key! Tumor vaccines are divided into preventive and therapeutic, and are injected to healthy people and cancer patients respectively preventive tumor vaccine is only targeted at tumors caused by microorganisms such as viruses, because it can be clear lying about the formation mechanism of tumors, so it can be prevented, there are a variety of vaccines on the market therapeutic tumor vaccine, there is now a cancer vaccine for prostate cancer on the market in the United States, several therapeutic products are in clinical trials therapeutic tumor vaccine is therapeutic for cancer patients, why is it called a vaccine? "The cancer vaccine is actually an immunotherapy, " Li Hangwen, founder and CEO of Smicromicro, a leading company of ," explained Li Hangwen, founder and CEO of Smicromicros, a leading domestic cancer vaccine company, to Science and Technology Daily For example, we use mRNA to express tumor antigens, tumor antigens like a marker (wearing red hats), it will alert and mobilize the police (immune system) to catch thieves, and red hats are thieves The immune system is then able to find thieves based on red hats and attack the tumor because the "portrait" of the immune system to recognize the principle of tumor and the principle of the role of the vaccine, so this immunotherapy is also known as the "tumor vaccine." " this is different from the method of introducing chemical and antibody drugs to foreign aid to combat power Tumor vaccines rely entirely on the body's own immune response to eliminate tumors Once immunotherapy is effective, it generally does not produce drug resistance, and the immune system "intelligently follows up" until the tumor is "lost," Li said Moreover, immunotherapy produces immune memory, and when the body is again exposed to the same pathogen attack, it quickly produces an immune response that eliminates the pathogen In traditional ways, it is easy to develop drug resistance, the tumor will "flow", if relapsed, may be more dangerous (Reporter Zhang Jiaxing) extended reading currently in Japan has not been approved for the original cancer vaccine
reported that "DCV cancer vaccine" technology from Japan, has been approved by the Ministry of Health, Labour and Welfare Japan's Ministry of Health, Labour and Welfare is one of the administrative bodies of the central government of Japan, equivalent to the China Health and Welfare Commission, but with slightly different jurisdictions The Ministry of Health, Labour and Welfare administers administrative units in the areas of health, medical care, children, welfare, care, employment, labor, pensions, as well as veterans of the armed forces and military units of war dead, and is also the central ministry with the largest budget of the Japanese government and the examination and recognition of pharmaceuticals, vaccines, medical devices, etc shall be commissioned by the Minister of Health and Labour to be implemented by the medical machinery integrated institution of the independent administrative legal person and made public to the public Professor Kitashi Haixiong of Nagasaki University in Japan told Science Daily that the story must be false Japan's Yano Yi Company has invested heavily in research on cancer vaccines, has an authoritative position, has entered the phase of the third phase of clinical trial analysis The Japanese government approved the U.S four-valent cervical cancer vaccine in May, and in May this year added a nine-valent cervical cancer vaccine, which is antigens of papillomavirus HPV No cancer vaccine has been approved in Japan secondly, the so-called vaccine for multiple cancers is still in the proof-of-concept phase and needs to be identified as a variant of the protein common to multiple cancers as antigens in clinical trials in different types of cancer patients This is a long validation process Therefore, there is no possibility of vaccine products for a wide range of cancers to be available at this time many hospitals in Japan are also doing various cancer treatments, including cancer vaccines, for foreigners, but these are free treatments Japan's national medical system is insurance medical care, insurance outside the scope of the Ministry of Health, Labour and Welfare is irresponsible.