17-year-old Biono award winner Rosbash's Scientific Reports paper

biological clock is one of many fascinating mysteries that can be found in life. This year's Nobel Prize in Physiology and Medicine went to three geneticists who study biological clocks, including Nobel Laureate Michael Rosbash, who published an article on the molecular mechanism of biological clocks in Scientific Reports on January 30, 2017.nobelprize.org
the circadian rhythmic behavior of living organisms is controlled by the generator signal path, which routes a series of neurons containing the biological clock. It is not known exactly what kind of correlation mechanism exists between these molecular biological clocks and the important network communication that manipulates the circadian rhythm generator path. To find out, this year's Nobel Prize has created a new fluorescent circadian rhythm monitoring mechanism in fruit flies that records the transcription and post-transcriptional rhythms of single cells in brain implants and in-body cultured neurons.
real-time imaging experiments and pharmacology combined with gene action, they found that a neuropeptide called pigment dispersion factor (PDF) enhances molecular rhythms. A transcription of an E-box biological clock start factor is performed in the generator neurons, and the pigment dispersion factor can regulate this transcription at different times of the day and under the influence of activity.the interaction between the pigment dispersion factor signal and the molecular biological clock. Sabado et al.
addition, they also found that the effect of pigment dispersion factors on the transcription of biological clock genes, and the known enhancement of PER/TIM stability, were carried out through two separate paths downstream of the pigment dispersion factor. The former relies on a mechanism that does not rely on cyclic adenotides (cAMP), while the latter relies on cycladenosine-protein kinase A (cAMP-PKA).
These results confirm and expand the understanding of pigment dispersion factors in controlling the synchronity of generator neurons, and the authors note that the real-time imaging experiments they use also provide new tools for studying important molecular-neural interactions in the circadian rhythm generator pathliness.
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