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    Home > Active Ingredient News > Endocrine System > 18 years of data in the Lancet sub-issue: The leading cause of death from diabetes is no longer cardiovascular

    18 years of data in the Lancet sub-issue: The leading cause of death from diabetes is no longer cardiovascular

    • Last Update: 2021-03-08
    • Source: Internet
    • Author: User
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    It is well known that diabetes can lead to a range of chronic vascular diseases, for cardiovascular disease, kidney disease, neurological damage these typical complications, there are more detailed guidelines and widely implemented secondary prevention.
    , are there any improvements in the current diabetes-related burden of death and what trends are changing? Heart disease and stroke are no longer the main causes of death in diabetics, and cancer, dementia and liver disease are making life more of a threat to diabetics, according to a new study by a team at Imperial College London.
    the study, the team analyzed data on 313,907 diabetics (including type 1 and 2) in the Health Database in England between 2001 and 2018 and matched the same number of healthy controls based on birth time and gender.
    first came with encouraging data: over 18 years, the overall survival of diabetics improved significantly, with mortality rates dropping by 32% for men and 31% for women.
    , non-diabetics showed a similar decline in mortality rates over the same period.
    , the survival gap remains largely unchanged compared to diabetics and non-diabetics.
    , the team explains, this is because heart disease and stroke-related deaths are reduced among all people, including people with diabetes.
    "this is due to improvements in risk factors such as smoking and blood pressure, as well as advances in medical treatment." dr Jonathan Pearson-Stuttard,
    study author at Imperial College London, said: "Vascular disease accounts for about 25 per cent of all diabetes deaths, up from 43 per cent about 20 years ago.
    , however, cancer mortality has improved much more slowly, and cancer deaths among people with diabetes have lagged behind the general population.
    " is that cancer is now the leading cause of death for diabetics in England (28 per cent of all diabetic deaths) and the biggest factor in the mortality gap between diabetics and non-diabetics.
    ," Dr. Pearson-Stuttard said.
    the reasons behind this study, but the team speculates that it may be related to overweight in diabetics, the main risk factor for cancer.
    18 years, the proportion of deaths attributable to dementia has also increased significantly, from 2 per cent of people with diabetes and 3 per cent of non-diabetics in 2011 to 16 per cent in 2018.
    Another mixed result was a decrease in the mortality rate of 10 of the 12 types of causes, including isoemia heart disease, stroke, other vascular diseases, diabetes-related cancers, other cancers, dementia, diabetes, liver disease, kidney disease, respiratory disease, other causes, injuries, and 10 specific causes of diabetes, the largest of which was is is bloody heart disease, stroke and direct death from diabetes.
    , however, deaths from dementia and liver disease are on the rise among people with diabetes.
    study also showed that diabetics were at higher risk than non-diabetics in almost all 12 leading causes of death.
    note that, in addition to cancer, people with diabetes are also particularly more likely to die from dementia (2 times), liver disease (2 times) or respiratory disease (1.8 times) in 2018 than non-diabetics.
    , diabetes and dementia are inextricably linked, such as sharing risk factors, including smoking, obesity and unhealthy diets.
    increased risk of liver disease may be due to general obesity and high levels of alcohol consumption in diabetics.
    team also acknowledged the limitations of the study, such as the fact that there is no distinction between type 1 and type 2 diabetes, and that about 20 per cent of people with diabetes in the UK are undiagnosed.
    But overall, based on these findings, the team called for updated diabetes guidelines to ensure that patients and clinicians understand the range of disease risks they face in addition to the complications of traditional concern, including cancer, dementia and liver disease.
    Edward Gregg, senior author of the study, added: "This study is yet another reminder that despite the decline in cardiovascular deaths, diabetes still causes a range of other health problems.
    the experience of the new crown outbreak, we need to look at the need for diabetes prevention and control from an increasingly broad perspective.
    In a commentary published in the same journal, Dr. Mingyang Song of Harvard University said vascular disease and diabetes are often classified as heart metabolic diseases, and while cancer has traditionally been seen as a separate disease, there is growing evidence of the importance of metabolic disorders in cancer.
    as cancer becomes the main cause of excessive death in diabetics, he adds several perspectives to early cancer screening, behavioral interventions and chemical prevention in diabetics.
    , for example, a healthy diet is universal for the prevention of diabetes and cancer.
    , diabetes has a long history, and it's important to determine the critical time window for cancer.
    that the cancer risk associated with diabetes peaks about eight years after the diagnosis of diabetes, intervention is particularly important in the first few years after diagnosis.
    chemical prevention, more and more data support the anti-cancer effects of metformin, but the impact of metformin on the risk of cancer secondary to diabetes still needs to be assessed.
    review concluded by stressing that while vascular complications have been the focus of clinical management of diabetes, this study highlights the assessment and prevention of risk of other diseases, such as cancer.
    : ( 1 ) Jonathan Pearson-Stuttard, et al., (2021). Trends in predominant causes of death in individuals with and without diabetes in England from 2001 to 2018: an epidemiological analysis of linked primary care records. The Lancet Diabetes & Endocrinology, DOI: Mingyang Song. (2021). Cancer overtakes vascular disease as leading cause of excess death associated with diabetes. The Lancet Diabetes & Endocrinology, DOI: Cancer leading cause of death among people with diabetes. Retrieved February 5, 2021, from
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