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Written | Edited by Wang Cong | Nagashi Typesetting | Shui Chengwen On March 28, 2021, Hong Kong TVB's famous old drama bone Liao Qizhi died of gastric cancer, arousing everyone's attention to gastric cancer.
In fact, China is the country with the largest number of cases and deaths from gastric cancer in the world.
According to the latest global cancer burden data released by the World Health Organization’s International Agency for Research on Cancer (WHO IARC) in 2020, the number of new cases of gastric cancer in the world will be 1.
089 million in 2020.
, The number of deaths was 768,000, including 478,000 new cases of gastric cancer in China (accounting for 43.
9%), and 373,000 deaths from gastric cancer (accounting for 48.
5%).
Details: Shenkan CA released the latest cancer data.
That is to say, China accounts for nearly half of the new cases and deaths of gastric cancer with 20% of the population.
So, what are the main reasons for the high incidence of gastric cancer in Chinese? How to prevent it? In October 2020, Academician Shen Hongbing, Professor Jin Guangfu of Nanjing Medical University, Professor Li Liming of Peking University, Professor Lv Jun, Professor Wei Qingyi of Fudan University, Professor Yang Ming of the Affiliated Tumor Hospital of Shandong First Medical University, etc.
in the top international academic journal The Lancet Oncology (The Lancet-Oncology) published the title: Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study (Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study (Genetic risk, incident gastric cancer, and healthy lifestyle) —Research papers based on genome-wide integration analysis and China's super-large prospective cohort study.
The largest genome-wide association analysis (GWAS) study of gastric cancer in the Chinese population so far shows that genetic risk and lifestyle are the two major factors leading to the high incidence of gastric cancer in Chinese people.
More importantly, adhering to a good lifestyle (not smoking, not drinking, eating less pickled food, eating more fresh fruits and vegetables) can significantly reduce the risk of gastric cancer in people with a high genetic risk of gastric cancer, which also reminds us to stick to it.
A good lifestyle and immediate genetic screening of gastric cancer risk can effectively prevent and treat gastric cancer.
Genetic variation and lifestyle are related to the risk of gastric cancer, but to what extent a healthy lifestyle can offset the genetic risk of gastric cancer is still unknown.
Therefore, the research team hopes to evaluate the benefits of a healthy lifestyle for individuals with high genetic risk by establishing a genetic risk model for gastric cancer.
In this meta-analysis and prospective cohort study, the research team first conducted a case-control study design in six independent genome-wide association analyses (GWAS) to fix the association between genetic variation and gastric cancer Effect meta-analysis.
The meta-analysis data set covers 21168 individuals of Han nationality, including 10254 patients with gastric cancer and 10914 cancer-free controls.
The research team identified 764 genetic variants that are significantly related to gastric cancer risk from about 7 million genetic variants, and constructed 5 gastric cancer polygenic risk scores with different significance thresholds (539 SNPs, 112 SNPs, and 38 SNPs).
, 18 SNPs, 12 SNPs).
Then, the research team compared these analysis data with the China Kadoorie Biobank (CKB), which is an independent, nationwide, and prospective cohort study that conducted over 10% of 100,220 people.
Years of prospective follow-up to evaluate the effectiveness of the polygenic risk score and the impact of a healthy lifestyle on the risk of gastric cancer.
A healthy lifestyle includes four points: not smoking, not drinking alcohol, eating less pickled foods, and eating more fresh fruits and vegetables.
Achieving these 4 points is considered a good lifestyle, those who achieve 2-3 points are considered as a normal lifestyle, and those who can only achieve 1 point or none are considered as a bad lifestyle.
The analysis results show that the five gastric cancer polygenic risk scores established by meta-analysis are all significantly related to the risk of gastric cancer, and the polygenic risk score model of 112 SNPs is most significantly related to the risk of gastric cancer.
Genetic risk and gastric cancer risk For genetic risk, compared with the 20% of people with the lowest genetic risk of gastric cancer, people with moderate genetic risk have a 54% increase in gastric cancer risk.
The 20% of people with the highest genetic risk of gastric cancer have a 108% increased risk of gastric cancer.
In other words, the higher the genetic risk of gastric cancer, the higher the risk of gastric cancer.
Lifestyle and the risk of gastric cancer.
Compared with people with healthy lifestyles, people with an average lifestyle increase the risk of gastric cancer by 34%, while people with poor lifestyles increase the risk of gastric cancer by 103%.
In other words, as the degree of poor lifestyle increases, the risk of gastric cancer also increases.
The study also found that even with a high genetic risk of gastric cancer, if you can adhere to a healthy lifestyle, that is, no smoking, no drinking, less pickled foods, and more fresh fruits and vegetables, the risk of gastric cancer will be reduced.
47%.
For people with low, medium, and high genetic risk of gastric cancer, if they adhere to a healthy lifestyle, the 10-year absolute risk of gastric cancer is reduced by 0.
82%, 0.
94%, and 1.
12%, respectively.
How to prevent gastric cancer This largest genome-wide association analysis study of gastric cancer for the Chinese population shows that genetic factors and lifestyle factors are two major factors that are independently related to the risk of gastric cancer.
The study clearly shows that people with high genetic risk of gastric cancer have a higher incidence, and people with poor lifestyles also increase the incidence of gastric cancer.
For those with high genetic risks, adhering to a good lifestyle can significantly offset their risk of gastric cancer.
.
This also reminds us that adhering to a good lifestyle can prevent gastric cancer, and those with high genetic risk of gastric cancer should be screened in time for early detection, which can greatly increase the therapeutic effect of gastric cancer and prolong survival.
Link to the paper: https://doi.
org/10.
1016/S1470-2045(20)30460-5 Open for reprint
In fact, China is the country with the largest number of cases and deaths from gastric cancer in the world.
According to the latest global cancer burden data released by the World Health Organization’s International Agency for Research on Cancer (WHO IARC) in 2020, the number of new cases of gastric cancer in the world will be 1.
089 million in 2020.
, The number of deaths was 768,000, including 478,000 new cases of gastric cancer in China (accounting for 43.
9%), and 373,000 deaths from gastric cancer (accounting for 48.
5%).
Details: Shenkan CA released the latest cancer data.
That is to say, China accounts for nearly half of the new cases and deaths of gastric cancer with 20% of the population.
So, what are the main reasons for the high incidence of gastric cancer in Chinese? How to prevent it? In October 2020, Academician Shen Hongbing, Professor Jin Guangfu of Nanjing Medical University, Professor Li Liming of Peking University, Professor Lv Jun, Professor Wei Qingyi of Fudan University, Professor Yang Ming of the Affiliated Tumor Hospital of Shandong First Medical University, etc.
in the top international academic journal The Lancet Oncology (The Lancet-Oncology) published the title: Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study (Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study (Genetic risk, incident gastric cancer, and healthy lifestyle) —Research papers based on genome-wide integration analysis and China's super-large prospective cohort study.
The largest genome-wide association analysis (GWAS) study of gastric cancer in the Chinese population so far shows that genetic risk and lifestyle are the two major factors leading to the high incidence of gastric cancer in Chinese people.
More importantly, adhering to a good lifestyle (not smoking, not drinking, eating less pickled food, eating more fresh fruits and vegetables) can significantly reduce the risk of gastric cancer in people with a high genetic risk of gastric cancer, which also reminds us to stick to it.
A good lifestyle and immediate genetic screening of gastric cancer risk can effectively prevent and treat gastric cancer.
Genetic variation and lifestyle are related to the risk of gastric cancer, but to what extent a healthy lifestyle can offset the genetic risk of gastric cancer is still unknown.
Therefore, the research team hopes to evaluate the benefits of a healthy lifestyle for individuals with high genetic risk by establishing a genetic risk model for gastric cancer.
In this meta-analysis and prospective cohort study, the research team first conducted a case-control study design in six independent genome-wide association analyses (GWAS) to fix the association between genetic variation and gastric cancer Effect meta-analysis.
The meta-analysis data set covers 21168 individuals of Han nationality, including 10254 patients with gastric cancer and 10914 cancer-free controls.
The research team identified 764 genetic variants that are significantly related to gastric cancer risk from about 7 million genetic variants, and constructed 5 gastric cancer polygenic risk scores with different significance thresholds (539 SNPs, 112 SNPs, and 38 SNPs).
, 18 SNPs, 12 SNPs).
Then, the research team compared these analysis data with the China Kadoorie Biobank (CKB), which is an independent, nationwide, and prospective cohort study that conducted over 10% of 100,220 people.
Years of prospective follow-up to evaluate the effectiveness of the polygenic risk score and the impact of a healthy lifestyle on the risk of gastric cancer.
A healthy lifestyle includes four points: not smoking, not drinking alcohol, eating less pickled foods, and eating more fresh fruits and vegetables.
Achieving these 4 points is considered a good lifestyle, those who achieve 2-3 points are considered as a normal lifestyle, and those who can only achieve 1 point or none are considered as a bad lifestyle.
The analysis results show that the five gastric cancer polygenic risk scores established by meta-analysis are all significantly related to the risk of gastric cancer, and the polygenic risk score model of 112 SNPs is most significantly related to the risk of gastric cancer.
Genetic risk and gastric cancer risk For genetic risk, compared with the 20% of people with the lowest genetic risk of gastric cancer, people with moderate genetic risk have a 54% increase in gastric cancer risk.
The 20% of people with the highest genetic risk of gastric cancer have a 108% increased risk of gastric cancer.
In other words, the higher the genetic risk of gastric cancer, the higher the risk of gastric cancer.
Lifestyle and the risk of gastric cancer.
Compared with people with healthy lifestyles, people with an average lifestyle increase the risk of gastric cancer by 34%, while people with poor lifestyles increase the risk of gastric cancer by 103%.
In other words, as the degree of poor lifestyle increases, the risk of gastric cancer also increases.
The study also found that even with a high genetic risk of gastric cancer, if you can adhere to a healthy lifestyle, that is, no smoking, no drinking, less pickled foods, and more fresh fruits and vegetables, the risk of gastric cancer will be reduced.
47%.
For people with low, medium, and high genetic risk of gastric cancer, if they adhere to a healthy lifestyle, the 10-year absolute risk of gastric cancer is reduced by 0.
82%, 0.
94%, and 1.
12%, respectively.
How to prevent gastric cancer This largest genome-wide association analysis study of gastric cancer for the Chinese population shows that genetic factors and lifestyle factors are two major factors that are independently related to the risk of gastric cancer.
The study clearly shows that people with high genetic risk of gastric cancer have a higher incidence, and people with poor lifestyles also increase the incidence of gastric cancer.
For those with high genetic risks, adhering to a good lifestyle can significantly offset their risk of gastric cancer.
.
This also reminds us that adhering to a good lifestyle can prevent gastric cancer, and those with high genetic risk of gastric cancer should be screened in time for early detection, which can greatly increase the therapeutic effect of gastric cancer and prolong survival.
Link to the paper: https://doi.
org/10.
1016/S1470-2045(20)30460-5 Open for reprint
