20 years of grinding a sword, "Science" magazine multiple papers reveal the key to HIV vaccine effectiveness

On the 26th, "Science" and its subsidiary Science Immunology published three papers in a row, revealing the key to an HIV vaccine being effective.

About 20 years ago, scientists at Oregon Health and Science University (Oregon Health and Science University) designed a new type of vaccine-cytomegalovirus (CMV) vaccine, which can completely eliminate the SIV virus in half of the monkeys.

A paper published by this university on the 26th found that the CMV vaccine they designed produces an unusual T cell response, which effectively fights SIV in monkeys.

Another paper from the University of Oxford in the United Kingdom mentioned that this special immune response brought by the CMV vaccine in monkeys is expected to be repeated in humans.

"Knowing the mechanism by which these CMV vaccines work in monkeys allows us to quickly determine the potential of human vaccines," said Professor Louis Picker, one of the leaders of the first paper.

Currently, a biotechnology company called Vir Biotechnology has obtained a license from Oregon Health and Science University and is evaluating the potential of human CMV vaccines to prevent HIV infection in a phase 1 clinical trial.

Reference materials:

[1] Daniel Malouli et al.

[2] Hongbing Yang et al.

[3] Marieke Verweij et al.

[4] HIV vaccine candidate's mysteries unlocked 20 years later, Retrieved March 25, 2021, from https://news.