2021 ACR Annual Meeting: Systemic lupus erythematosus is a risk factor for death in elderly patients with early breast cancer

Purpose : Women with systemic lupus erythematosus (SLE) and breast cancer (BC) may receive different treatments (such as radiotherapy) than women with BC who do not have SLE .
Women suffering from SLE and BC may have more comorbidities that affect survival .
The goal of the study was to compare the survival rates of women with SLE and BC with women with BC alone or with SLE without cancer .

PurposePurpose : Women with systemic lupus erythematosus (SLE) and breast cancer (BC) may receive different treatments (such as radiotherapy) than women with BC who do not have SLE .

Women suffering from SLE and BC may have more comorbidities that affect survival .
The goal of the study was to compare the survival rates of women with SLE and BC with women with BC alone or with SLE without cancer .

Methods : The study included women ≥ 66 years of age who were diagnosed with BC between 2005 and 2015 , and a 5% non-cancer random sample living in the same area .

According to the status of BC and SLE , the study subjects were divided into three groups: 1) BC SLE , 2) BC non- SLE , 3) non-cancer SLE .
For women with BC , the study collected cancer characteristics (age and year at diagnosis, stage, hormone receptor status) and treatment (chemotherapy, radiotherapy, and type of surgery) .
The cancer characteristics of BC SLE and BC non- SLE match .

 Methods The study included women ≥ 66 years of age who were diagnosed with diagnosed BC between 2005 and 2015 , and a 5% non-cancer random sample living in the same area .
According to the status of BC and SLE , the study subjects were divided into three groups: 1) BC SLE , 2) BC non- SLE , 3) non-cancer SLE .
For women with BC , the study collected cancer characteristics (age and year at diagnosis, stage, hormone receptor status) and treatment (chemotherapy, radiotherapy, and type of surgery) .
The cancer characteristics of BC SLE and BC non- SLE match .
Non-cancer SLE women matched the birth year and race of BC SLE .
Kaplan-Meier method and multivariateThe Cox proportional hazards model is used to evaluate the association between survival outcomes and the Garris index (for SLE only ) group that adjusts for cancer characteristics and treatment (for BC ), comorbidities, and severity of SLE disease .

ResultsResults : study identified 494 embodiment BC of SLE , 145517 embodiment BC non of SLE , and a matching of 268 cases of non-cancer of SLE

ConclusionConclusion : The study data show that the suffering individual BC compared to patients suffering from BC and SLE patients at risk of earlier death, adjusting SLE risks remain after the disease activity and complications

Bruera S, Lei X, Pundole X, Zhao H, Giordano S, Vinod S, Suarez-Almazor M.

Systemic Lupus Erythematosus Is a Risk Factor for Mortality in Older Patients with Early-Stage Breast Cancer [abstract].
Arthritis Rheumatol.

Bruera S, Lei X, Pundole X, Zhao H, Giordano S, Vinod S, Suarez-Almazor M.

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