2022-04-19 PNAS Zhou Congzhao and Chen Yuxing's research group discovered a novel regulatory mechanism of the human phospholipid flipperase ATP8B1

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The research group of Professor Zhou Congzhao and Professor Chen Yuxing of our hospital analyzed the three-dimensional structure of human phospholipid flippase ATP8B1-CDC50 and its complex with the physiological substrate phosphatidylserine by single particle cryo-electron microscopy, and clarified the ATP8B1 through a series of biochemical experiments .

Asymmetry of lipid bilayers is a hallmark feature of eukaryotic cell membranes, maintaining a range of cellular functions, such as membrane stability, cell shape, cell signaling, and bile and cholesterol homeostasis

Combining the in vitro ATP hydrolysis activity and the detection of lipid turnover activity based on fluorescent labeling, the researchers demonstrated for the first time that phosphatidylserine is the true physiological substrate of

Figure 1.

Professor Zhou Congzhao, Professor Chen Yuxing and Associate Professor Hou Wentao are the co-corresponding authors of the paper, and Ph.

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