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▎Editor of WuXi AppTec's content team Recently, an examiner in Xi'an City was diagnosed with a new crown case after completing two doses of the new crown vaccine, causing concern.
In this regard, Mr.
Wang Huaqing, chief expert of the China Centers for Disease Control and Prevention's immunization program, said at a press conference that relevant information is still being understood and verified, including the history of vaccination and the development of infection.
At the same time, although the vaccine may fail to protect individual individuals, it can protect most people from the disease, thereby establishing herd immunity to play a role.
Today, the "New England Journal of Medicine" published 3 newsletters, and the vaccination data of medical staff from different large overseas medical institutions also confirmed that although individual patients became ill after vaccination, the overall view of the vaccine has a significant protective effect on medical staff .
Screenshot source: The New England Journal of Medicine.
The first study from the University of California, San Diego (UCSD) and University of California, Los Angeles (UCLA) teams analyzed a total of 36,659 medical staff in their medical systems as of February 9th that were vaccinated with Pfizer/BNT162b2 Or the effect of Moderna's new crown vaccine, of which 28,184 people (77%) have already received the second dose of vaccine.
Before and after vaccination, these medical institutions have initiated routine testing of asymptomatic people.
Among all the vaccinated health care workers, at least 379 people tested positive for the new crown at least 1 day after vaccination, and most of them (71%) tested positive within the first 2 weeks after the first dose.
Among the medical staff who received two doses of the vaccine, 37 people tested positive, of which 22 tested positive within one week of the second dose, only 8 tested positive 8-14 days after the second dose, and 7 tested positive The second dose was tested positive 15 days after vaccination.
Among all 14,990 people who received the second dose of vaccine for more than 2 weeks, the positive rate was 0.
05%.The absolute risks of being positive for new crowns after UCSD and UCLA medical staff are vaccinated are 1.
19% and 0.
97%, respectively, which are higher than the data in clinical trials of the two mRNA vaccines.
Potential reasons include the surge in overall infections in Southern California during the vaccination period, the risk of infection among medical staff is also higher than that of subjects in clinical trials, and the frequency of testing asymptomatic employees by medical institutions is higher than in trials.
However, 14 days after the second dose of the vaccine, the positive rate dropped sharply, indicating that the efficacy of the vaccine has been maintained in the real world environment.
It also emphasizes the need to continue to wear masks, maintain social distancing, and conduct routine symptom screening and testing.
, Until the formation of herd immunity.
Screenshot source: The New England Journal of Medicine The second study comes from the Hadassah Hebrew University Medical Center in Israel.
The hospital has 6,680 employees and conducts regular screenings on all employees.
From the outbreak to January 13 this year, a total of 689 medical staff (10.
3%) were infected with the new crown.
This high infection rate is mainly due to community exposure, and the incidence is similar to the overall situation in Jerusalem where the hospital is located.
Beginning on December 20, 2020, all 5,297 medical staff who were not infected at the time were vaccinated with Pfizer/BNT162b2 new crown vaccine.
Among the medical staff who remained uninfected 21 days after the first dose, 98.
9% continued to receive the second dose.
In the vaccinated population, the morbidity and infection rate decreased significantly after the second week of the first dose, and began to remain at a low level in the fourth week.
▲The weekly new infection rate after the first dose of vaccine (the vertical line represents the 95% confidence interval) (picture source: reference [2]) These findings show that even if the new crown infection rate in the community is high, vaccination can still be common Effectively protect medical staff.
Screenshot source: The New England Journal of Medicine.
The third study from the University of Texas Southwestern Medical Center reported on the protective effects of mRNA vaccines for front-line medical staff.
In the first 31 days of starting vaccination, 59% of all 23,234 health care workers received one of the two mRNAs, and 30% received the second dose.
During the period from December 15, 2020 to January 28, 2021, 350 (1.
5%) of all these medical staff developed new infections.
Among them, the infection rate of the unvaccinated population was 2.
61% (234/8969).
The infection rate of the population receiving one dose was 1.
82% (112/6144 people), and the infection rate of the population receiving two doses was 0.
05% (4 people/8121 people), and the difference was statistically significant.
▲The infection rate of medical staff who were not vaccinated, vaccinated with one dose and vaccinated with two doses (picture source: reference [3]) On the other hand, starting from January 9th, the positive rate of new crown among all medical staff has always been lower than the same period Positive rate among emergency patients.
▲25 days after the start of vaccination (red line) (blue line), the infection rate among medical staff was significantly lower than the expected trend (black line) (picture source: reference [3]) These data show that vaccination protects medical staff Is huge.
In fact, the number of quarantined employees in the hospital has also been reduced by more than 90%.
New crown research related reading "The Lancet" is heavy! 6.
9% of the Wuhan population is positive for the new crown antibody, 82% of them are asymptomatic, and 40% have long-term neutralizing antibodies.
What is the risk of secondary infection with the new crown? "Lancet" published the largest population study to date.
Are there many allergic reactions to the mRNA new crown vaccine? JAMA published data on the safety of vaccinations for over 60,000 people, reducing 92% of new crown infections and 94% of cases.
NEJM published data on Pfizer/BioNTech vaccines for 600,000 people in Israel.
Source: 123RF reference materials [1] Jocelyn Keehner, et al.
, ( 2021).
SARS-CoV-2 Infection after Vaccination in Health Care Workers in California.
The N Engl J Med, DOI: 10.
1056/NEJMc2101927[2] Shmuel Benenson, et al.
, (2021).
NT162b2 mRNA Covid-19 Vaccine Effectiveness among Health Care Workers.
The N Engl J Med, DOI: 10.
1056/NEJMc2101951[3] William Daniel, et al.
, (2021).
arly Evidence of the Effect of SARS-CoV-2 Vaccine at One Medical Center.
The N Engl J Med, DOI: 10.
1056/NEJMc2102153[4] March 21: Press conference of the Joint Prevention and Control Mechanism of the State Council: Introduction to the safety and effectiveness of the new coronavirus vaccine.
Retrieved March 22, 2021, from http:// .
cn/xinwen/gwylflkjz152/index.
htm Note: This article aims to introduce the progress of medical and health research, not a treatment plan recommendation.
If you need guidance on treatment plans, please go to a regular hospital for treatment.
In this regard, Mr.
Wang Huaqing, chief expert of the China Centers for Disease Control and Prevention's immunization program, said at a press conference that relevant information is still being understood and verified, including the history of vaccination and the development of infection.
At the same time, although the vaccine may fail to protect individual individuals, it can protect most people from the disease, thereby establishing herd immunity to play a role.
Today, the "New England Journal of Medicine" published 3 newsletters, and the vaccination data of medical staff from different large overseas medical institutions also confirmed that although individual patients became ill after vaccination, the overall view of the vaccine has a significant protective effect on medical staff .
Screenshot source: The New England Journal of Medicine.
The first study from the University of California, San Diego (UCSD) and University of California, Los Angeles (UCLA) teams analyzed a total of 36,659 medical staff in their medical systems as of February 9th that were vaccinated with Pfizer/BNT162b2 Or the effect of Moderna's new crown vaccine, of which 28,184 people (77%) have already received the second dose of vaccine.
Before and after vaccination, these medical institutions have initiated routine testing of asymptomatic people.
Among all the vaccinated health care workers, at least 379 people tested positive for the new crown at least 1 day after vaccination, and most of them (71%) tested positive within the first 2 weeks after the first dose.
Among the medical staff who received two doses of the vaccine, 37 people tested positive, of which 22 tested positive within one week of the second dose, only 8 tested positive 8-14 days after the second dose, and 7 tested positive The second dose was tested positive 15 days after vaccination.
Among all 14,990 people who received the second dose of vaccine for more than 2 weeks, the positive rate was 0.
05%.The absolute risks of being positive for new crowns after UCSD and UCLA medical staff are vaccinated are 1.
19% and 0.
97%, respectively, which are higher than the data in clinical trials of the two mRNA vaccines.
Potential reasons include the surge in overall infections in Southern California during the vaccination period, the risk of infection among medical staff is also higher than that of subjects in clinical trials, and the frequency of testing asymptomatic employees by medical institutions is higher than in trials.
However, 14 days after the second dose of the vaccine, the positive rate dropped sharply, indicating that the efficacy of the vaccine has been maintained in the real world environment.
It also emphasizes the need to continue to wear masks, maintain social distancing, and conduct routine symptom screening and testing.
, Until the formation of herd immunity.
Screenshot source: The New England Journal of Medicine The second study comes from the Hadassah Hebrew University Medical Center in Israel.
The hospital has 6,680 employees and conducts regular screenings on all employees.
From the outbreak to January 13 this year, a total of 689 medical staff (10.
3%) were infected with the new crown.
This high infection rate is mainly due to community exposure, and the incidence is similar to the overall situation in Jerusalem where the hospital is located.
Beginning on December 20, 2020, all 5,297 medical staff who were not infected at the time were vaccinated with Pfizer/BNT162b2 new crown vaccine.
Among the medical staff who remained uninfected 21 days after the first dose, 98.
9% continued to receive the second dose.
In the vaccinated population, the morbidity and infection rate decreased significantly after the second week of the first dose, and began to remain at a low level in the fourth week.
▲The weekly new infection rate after the first dose of vaccine (the vertical line represents the 95% confidence interval) (picture source: reference [2]) These findings show that even if the new crown infection rate in the community is high, vaccination can still be common Effectively protect medical staff.
Screenshot source: The New England Journal of Medicine.
The third study from the University of Texas Southwestern Medical Center reported on the protective effects of mRNA vaccines for front-line medical staff.
In the first 31 days of starting vaccination, 59% of all 23,234 health care workers received one of the two mRNAs, and 30% received the second dose.
During the period from December 15, 2020 to January 28, 2021, 350 (1.
5%) of all these medical staff developed new infections.
Among them, the infection rate of the unvaccinated population was 2.
61% (234/8969).
The infection rate of the population receiving one dose was 1.
82% (112/6144 people), and the infection rate of the population receiving two doses was 0.
05% (4 people/8121 people), and the difference was statistically significant.
▲The infection rate of medical staff who were not vaccinated, vaccinated with one dose and vaccinated with two doses (picture source: reference [3]) On the other hand, starting from January 9th, the positive rate of new crown among all medical staff has always been lower than the same period Positive rate among emergency patients.
▲25 days after the start of vaccination (red line) (blue line), the infection rate among medical staff was significantly lower than the expected trend (black line) (picture source: reference [3]) These data show that vaccination protects medical staff Is huge.
In fact, the number of quarantined employees in the hospital has also been reduced by more than 90%.
New crown research related reading "The Lancet" is heavy! 6.
9% of the Wuhan population is positive for the new crown antibody, 82% of them are asymptomatic, and 40% have long-term neutralizing antibodies.
What is the risk of secondary infection with the new crown? "Lancet" published the largest population study to date.
Are there many allergic reactions to the mRNA new crown vaccine? JAMA published data on the safety of vaccinations for over 60,000 people, reducing 92% of new crown infections and 94% of cases.
NEJM published data on Pfizer/BioNTech vaccines for 600,000 people in Israel.
Source: 123RF reference materials [1] Jocelyn Keehner, et al.
, ( 2021).
SARS-CoV-2 Infection after Vaccination in Health Care Workers in California.
The N Engl J Med, DOI: 10.
1056/NEJMc2101927[2] Shmuel Benenson, et al.
, (2021).
NT162b2 mRNA Covid-19 Vaccine Effectiveness among Health Care Workers.
The N Engl J Med, DOI: 10.
1056/NEJMc2101951[3] William Daniel, et al.
, (2021).
arly Evidence of the Effect of SARS-CoV-2 Vaccine at One Medical Center.
The N Engl J Med, DOI: 10.
1056/NEJMc2102153[4] March 21: Press conference of the Joint Prevention and Control Mechanism of the State Council: Introduction to the safety and effectiveness of the new coronavirus vaccine.
Retrieved March 22, 2021, from http:// .
cn/xinwen/gwylflkjz152/index.
htm Note: This article aims to introduce the progress of medical and health research, not a treatment plan recommendation.
If you need guidance on treatment plans, please go to a regular hospital for treatment.
