"320 Courtyard": Open a new chapter in history

the Shanghai Institute of Life Sciences of the Chinese Academy of Sciences gate (1) for the first time from the molecular level successfully sketched Tet double oxygenase and TDG glycoside enzyme-mediated DNA active demethylation path(2) at the end of 2017 born two somatic cell clone monkeys - "Chinese" and "Huahua"(3) single chromosome(3) single chromosome equieryeast The pilot cells (rose red) guide hematopoietic stem cells (red) into the vascular microencology Shanghai Yueyang Road 320, is the cradle of a number of modern life science research institutions in New China, since 1999, as the Chinese Academy of Sciences Shanghai Institute of Life Sciences (hereinafter referred to as the Shanghai Academy of Biological Sciences) and its own research institutes (centers), has been affectionately known by scientists as the "320 compound."
years, the Chinese Academy of Sciences has just completed a "first move" program to deploy the deepening reform. After three years, the Shanghai Academy of Health Sciences "incubates" four "first action" program four types of institutions, namely, the Chinese Academy of Sciences Center for Excellence in Molecular Cell Science Innovation, the Chinese Academy of Sciences Center for Brain Science and Intelligent Technology Excellence innovation, the Chinese Academy of Sciences Center for Excellence in Molecular Plant Science Innovation and the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences. Four institutions have been approved in May this year to become independent central scientific research institutions.
July 23, 2019, the Chinese Academy of Sciences summarized the reform efforts in Shanghai. Wang Keqiang, deputy secretary-general of the Chinese Academy of Sciences, conveyed the important instructions of Bai Chunli, president of the Chinese Academy of Sciences and secretary of the Party Group, at the wrap-up meeting. Bai Chunli gave full recognition to the efforts and contributions made by the leadership team of the four entity scientific research institutions and the vast number of scientific researchers to this end, and warmly congratulated the great innovation energy released and stimulated through the deepening reform, especially the series of major innovation achievements made in recent years, and called for a careful summary of the experience of deepening the reform and a solid follow-up work. Zhang Yaping, vice president of the Chinese Academy of Sciences and a member of the Party Group, pointed out that under the correct leadership of the Party Group of the Academy, deepening the reform of the Shanghai Academy of Health Sciences has been fully completed, with remarkable results, and has strongly promoted the innovation and development of life science and health in Shanghai.1999, eight independent legal person research institutes (centers) in the field of life sciences in Shanghai were established as a legal entity of the Shanghai Academy of Health Sciences. After more than 10 years of deployment, the Shanghai Academy of Health Sciences has become a large institution with more than a dozen research institutes (centers). This includes both traditional research institutes and independent new research institutes, including domestic and international research institutes, covering the basic frontiers of life and health, population health and modern agriculture in the field of discipline.
Shanghai Academy of Health Sciences has repeatedly topped the national life sciences list in the Nature Index's annual list, and has been named China's institution of the year by Cell Press for several years.
, under the surface of the "prosperity", the development barrier is becoming more prominent. The corporate governance system is difficult to highlight the status of the main body of scientific and technological innovation of the Institute (center), to mobilize the enthusiasm of the micro-innovation subject, the management authority and responsibility is not unified, the operational efficiency is not high, the support service work is difficult to adapt to the needs, the external competitiveness is severely restricted by the system, the cohesion and attraction of talent capacity is weakening, and so on.
Shanghai Academy of Health Sciences leadership team and research institutes (centers) team analysis of the status quo agreed that although the apparent state is good, but if the development of such a trend, innovation vitality will continue to be constrained, developing problems and risks will be further accumulated, scientific and technological innovation capabilities and competitiveness will be weakened. And the world's scientific and technological development, especially the development of life science is changing rapidly, "reverse water boat, do not advance is retreating, not fast progress and retreat", the current institutional mechanism has reached the point of non-changeable!In 2014, the Chinese Academy of Sciences "Take the Lead" program and the Institute classification reform was fully launched, the Brain Science Innovation Center for Excellence (now the Brain Science and Intelligent Technology Innovation Center for Excellence) became the first preparatory institutions, and in 2015, two centers of excellence in molecular cell science and molecular plant science were approved for construction, providing a rare opportunity and good conditions for solving the problems of the Shanghai Academy of Health Sciences. In July 2015, deepening the reform of the Shanghai Academy of Health Sciences was officially included in the agenda of the Chinese Academy of Sciences.
after nearly a year of deliberation and preliminary research, in April 2016, the Chinese Academy of Sciences set up a leading group and working group to deepen the reform of the Shanghai Academy of Health Sciences. In June, Wang Keqiang led a working group to conduct a special study at the Shanghai Academy of Health Sciences, and listened extensively and in depth to the opinions and suggestions of more than 100 scientists, management backbones and old leaders.
less than a month, a "Deepening the Reform Program of the Shanghai Institute of Life Sciences" (hereinafter referred to as the Program) was published. "The importance, necessity and urgency of deepening reform under the new situation are generally widely among the cadres and workers of the Shanghai Academy of Health Sciences, and the calls for reform are very high," the plan reads. The
put forward the idea of deepening the reform guiding ideology with "thinking for development, solving problems for reality and being responsible for history", and adopted the idea of combining "untie" and "integration". In this regard, Li Lin, president of the Shanghai Academy of Health Sciences, pointed out that "untie" is to reduce the development of better and faster research institutes by the constraints, so that they develop better and faster;
the implementation level, the program proposes to divide the subject area layout into molecular cells, brain science, molecular plants, population health and other four focus areas. Among them, the first three areas are mainly aimed at "facing the forefront of science and technology in the world", while the field of population health is mainly aiming at "facing the main battleground of the national economy".The
program proposes that, in order to break down the key problem of "first-level legal person and two-level management", it is proposed to promote the establishment of research institutions with independent legal persons in three directions: molecular cells, brain science and molecular plants, and to explore the substantive management and operation mechanism of the center of excellence. Other research modules are integrated into entity scientific research institutions in the field of population health, and independent legal entities are also established.
this deepening reform program fully respects the law of development in the field of life sciences, conforms to the strong desire of the broad masses of scientific research and management backbone, and has been widely supported and generally supported by all. Soon, on July 22, 2016, the program was approved by the Office of the President of the Chinese Academy of Sciences.
In order to push forward the reform as soon as possible, since November 2016, four entity research institutions, without the approval of legal entities, first implemented a "plan list" within the Chinese Academy of Sciences, including scientific research, administration, party building and other work, as the Chinese Academy of Sciences directly under the management of legal entities scientific research institutions, took the first step.
the east wind of the "take the lead" plan, the trumpet of deepening reform is blowing, and the blueprint for the development of the "320 compound" has been drawn up. if the reforms outline the overall outline of the future development of the "320 compound", the details will need to be worked out by scientists.
for every centre of excellence, the first priority after "unbusting" is positioning. For example, the Center for Excellence and Innovation in Molecular Cell Science aims to achieve landmark results in explaining the nature of cell life and the laws of activity, with the goal of "cell fate decision and molecular regulation", a leading issue in life sciences.
" Center for Excellence and Innovation in Molecular Cell Science has dual meaning, one is the body, the other is the soul. Li Lin, the center's chief scientist, said that "body" refers to the entity of a scientific institution that has obtained legal personality, while "soul" refers to the scientific highlands it wants to build in its field of study. Relying on the "body", play the overall advantages of the Chinese Academy of Sciences, the formation of an international leading position of scientific research team.
Innovation Center for Brain Science and Intelligent Technology was jointly built by the Institute of Neuroscience of the Chinese Academy of Sciences and the Institute of Automation of the Chinese Academy of Sciences. This is the first time in the world to achieve the substantive integration of brain science and intelligent technology.
The center's director Pu Muming took the lead in automating the "squatting point" and formed a squat exchange system, the two areas most in need of cross-cutting finally "accept each other", for the development of brain science and the implementation of the "Chinese Brain Plan" laid a solid foundation.
The Center for Excellence and Innovation in Molecular Plant Science closely follows the scientific question of "The Nature and Law of Plant Life Phenomenon" and determines four research directions, such as genetic basis and evolutionary law, developmental process regulation, environmental interoperability and response, and material energy metabolism.
" so that research institutions can form joint efforts, collaborative innovation and breakthroughs on major scientific issues. He Zuhua, a researcher at the Shanghai Institute of Plant Physiology and Ecology, commented, "The classification reform is conducive to avoiding homogenization competition, to organizing and implementing major research projects, assembling scientists in related research fields, serving the needs of national strategies, breaking through cutting-edge theories and technologies, and solving the problem of 'card neck'." For
more than three years, three centres of excellence have demonstrated the effectiveness of this reform with excellent transcripts.
landmark results show a mass outbreak situation, seven (cooperation) results were selected in 2016 and 2018 China's top 10 scientific progress, including revealing the advantages of rice yield syndrome hybrid molecular genetic mechanism, proposed a new method of tumor immunotherapy based on cholesterol metabolic regulation, the discovery of sperm RNA As a memory carrier, it will obtain cross-generational inheritance of sexual features, build the world's first model of non-human primate autism, reveal the mechanism of oscic genetic regulation of key signaling pathfles in embryonic development, successfully clone macaques based on soliton cell nuclear transplantation technology, and create the first artificial monochromosome organs. "Molecular structure and variety design of high-yielding high-quality features of rice" won the first prize of the 2017 National Natural Science Award.
In terms of taking on major tasks, each of the three centers of excellence led a strategic pilot project of the Chinese Academy of Sciences, "deseration division and sperm health" and "whole brain neural connection map and clone monkey model plan" were approved by shanghai municipal science and technology major special projects, the National Natural Science Foundation of China Basic Science Center project "Future Crop Molecular Design" was approved. The National Protein Facility (Shanghai) was built and delivered to the Zhangjiang Comprehensive National Science Center in Shanghai, which was hailed as a "national weapon" by General Secretary Xi Jinping.
in the eyes of researchers, this reform is not only the harvest of scientific research results, but also the full release of human innovation vitality.
" Center of Excellence has worked well to stabilize talent. Liu Xiaolong, director of the Center for Excellence and Innovation in Molecular Cell Science, commented that in the process of reform, it is inevitable that there will be a large flow of talents, and the flexible way of talent organization of the Center of Excellence has made the organization of scientific research teams avoid contradictions such as personnel relations changes, giving talents greater autonomy.
The Center for Excellence and Innovation in Brain Science and Intelligent Technology has established the idea of integrating science and education work "to promote the full exchange of cross-research and to cultivate the bold integration of cross-talents", and launched the dual-mentor postgraduate training system, which is more conducive to the implementation of the cross-integration and team attack system.
2018, three young scientists from the Center for Excellence and Innovation in Molecular Plant Science received funding from the National Science Fund for Distinguished Young People, and five scientists were selected as leaders of the National Special Support Program for High-Level Talents. Han Bin, director of the center, said: "We want to develop talented people into outstanding talent." "Such achievements, before the reform is not dare to think.
the end of 2018, following the "single flight" of three centres of excellence, the field of population health officially entered the "First Action" program under the name of "Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences". As Li Lin, director, said, "Integrating and forming the Institute of Nutrition and Health Characteristics is not only a difficulty in deepening the reform of the Shanghai Academy of Health Sciences, but also an important symbol of the success of deepening the reform".
Today, the Institute of Nutrition and Health, which is integrated by the "three houses and two centers", has achieved "three unitys" in planning, layout and management through deepening reform, and the talent pool has been integrated according to research direction and key tasks, and the integration of nutrition, data and health has been realized institutionally. It mainly faces the main battlefield of national economy, focuses on the strategic orientation of basic and applied basic research, and achieves the misalposition development with the three centers of excellence mentioned above. The Institute of Nutrition and Health after the
inspiration" also confirmed the effectiveness of the reform with beautiful transcripts: over the past two years, five people have received funding from the National Science Fund for Distinguished Young People;
reform has never been the goal, and the purpose of deepening reform is to solve the outstanding problems faced by the reform and innovation development of the Shanghai Academy of Health Sciences, release and stimulate the vitality of innovation, and accelerate the development of innovation. Starting from the actual situation, the Party Group of the Chinese Academy of Sciences, under the situation that most of the other types of scientific research institutions in the research institute classification reform are integrated and merged, does not engage in "one size fits all", fully respects the law of scientific and technological development and scientific and technological innovation activities in the field of life sciences and health, and promotes innovation and development by deepening the reform of institutional mechanisms. This is an important experience for the smooth progress and success of deepening reform.
the frontiers of science is never ending, and reform and innovation are always on the way. Open a new chapter in history, for the "320 compound" of many scientific researchers, the times in change, institutions in change, scientific research direction in change, always unchanged is the "320 spirit" passed down from generation to generation of scientists, which is the pursuit of excellence in the scientific spirit, the spirit of reform, the spirit of innovation for the people ...