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    Home > Biochemistry News > Biotechnology News > 3D printing of the human heart is no longer a dream, bringing good news to patients who need heart transplants

    3D printing of the human heart is no longer a dream, bringing good news to patients who need heart transplants

    • Last Update: 2020-06-02
    • Source: Internet
    • Author: User
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    This technology, called Freeform Hydrogel Free Reversible of Suspended Hydrogel, FRESH, allows these researchers to overcome many of the challenges associated with existing 3D bioprinting methods and use soft biomaterials for unprecedented resolution and fidelityevery organ in the body, such as the heart, is constructed from specialized cells that are kept together by biological stents called extracellular matrix (ECM)This network of ECM proteins provides the structural and biochemical signals that cells need to perform their normal functionsUntil then, however, it was not possible to reconstruct this complex ECM structure using traditional biomanufacturing methods"What we're showing is that we can use cells and collagen to print out many really functioning parts of the heart, such as heart valves, or smaller throbbing ventricle," said Adam Feinberg, author of thepaper and professor of biomedical engineering at Carnegie Mellon University and professor of materials science and engineeringBy using MRI data from the human heart, we are able to accurately reconstruct the patient's unique anatomy and use collagen and human heart cells for 3D bioprintingmore than 4,000 patients in the United States are waiting for a heart transplant, and in other parts of the world outside the U.S., millions of patients need a heart but are not eligible for a heart transplant waiting listThe need for organ replacement is enormous, and new methods are needed to design artificial organs that can repair, replenish or replace long-term organ functionAs a member of Carnegie Mellon University's Bioengineered Organ Initiative, Feinberg is working to address these challenges by building a new generation of bioengineered organs that more closely reproduce the structure of natural organs"Collagen is an ideal 3D printed biomaterial that makes up almost every tissue in the human body," explains Andrew Hudson, co-author of thepaper and a doctoral student at Feinberg LaboratoryHowever, the reason 3D printing is so difficult is that it starts out as liquid and deformed easily, so if you want to print it in the air, it will only form glue on your construction platformSo we developed a technique to prevent it from deformingThis FRESH 3D bioprinting method developedFeinberg lab allows collagen to be deposited layer by layer in a support bath consisting of gels, giving collagen the opportunity to cure in place before being removed from the support grooveBy using FRESH, the supporting gel can be easily melted out by heating the support ingresin from room temperature to body temperature after 3D bioprinting In this way, the researchers were able to remove the supporting gel without damaging the bioprinting structure made up of collagen or cells this approach is very exciting for the field of 3D bioprinting because it allows collagen stents to bioprint on the size of human organs It's not limited to collagen, because a variety of other soft gels, including fibrin, alginate and hyaluronic acid, can use FRESH technology for 3D bioprinting, providing a powerful and adaptable tissue engineering platform Importantly, these researchers have also developed open source design methods, so that almost anyone, whether they are working in a medical laboratory or studying high school science, can build and obtain a low-cost, high-performance 3D bioprinter looking to the future, FRESH has applications in many aspects of regenerative medicine, from wound repair to organ bioengineering, but it is only part of an evolving field of biomanufacturing "What we're really talking about is the convergence of technology," Feinberg said Not only is my lab doing bioprinting research, but other laboratories and small companies in the fields of stem cell science, machine learning, and computer simulation are also doing this research, and many are developing new 3D bioprinting hardware and software Feinberg added, "It's important to understand that there are still many years of research that hasn't been done, but we should still be very excited because we're making real progress in building functional human tissues and organs, and this paper is a step along that path." " References: 1 A Lee el al.3D printing of collagen to rebuild components of the human heart Science, 2019, doi:10.1126/science.aav9051 2 Q Dasgupta el al A FRESH SLATE for 3D bioprinting Science, 2019, doi:10.1126/science.aay0478 3.3-D the human hearthttps://medicalxpress.com/news/2019-08-d-human-heart.html original title: Heavy! 3D printing of the human heart is no longer a distant dream
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