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    Home > Biochemistry News > Biotechnology News > 3D printing of the human heart solves the problem for patients with advanced heart disease.

    3D printing of the human heart solves the problem for patients with advanced heart disease.

    • Last Update: 2020-10-01
    • Source: Internet
    • Author: User
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    According to the World Health Organization (WHO), there are 17.9 million deaths from cardiovascular disease each year, making it the leading cause of death worldwide.
    heart transplants are often an important option for treating patients with advanced heart disease.
    , according to the WHO Donation and Transplant Observation Report, only about 3,500 heart transplants are performed globally each year.
    therefore, alleviating the difficulties of heart transplants requires ensuring a sustainable supply of vital organs.
    Bio-ink-breaking mission Over the past year, academic institutions such as the University of Minnesota and Tel Aviv University (TAU) in Israel have developed bio-inks that can be used to 3D print a fully functional human heart.
    With the help of successfully developed bio-inks, cell vitality can be promoted, and induced pluripotent stem cells multiply and then differentiate into heart muscle cells, achieving the critical cell density required for heart cells to beat like a normal heart.
    breakthrough, which had previously been seen almost as an impossible task.
    BioLife4D is the first U.S. company in the U.S. to successfully print out a tiny heart with a complete heart structure using 3D biology.
    3D Systems, an original 3D printing technology organization, recently teamed up with OpHeart, a nonprofit organization, to provide pediatric heart surgeons with 3D printing tools to help them better prepare and practice complex operations.
    3D printing of vital tissues and organs will play a key role in alleviating organ shortages.
    3D-printed heart can be a solution to heart health problems around the world, after completely solving the complex problems and logistics of 3D bioprinting.
    , it will take a decade for the 3D-printed heart to finally be put into use, and it may take up to 10 years, for several reasons.
    , the current 3D-printed heart size is closer to the rabbit heart than the human heart size.
    , the current size of the 3D-printed heart may be a problem, especially given the obesity that is often associated with cardiovascular disease.
    But a 2006 publication by the Heart Rhythm Society (HRS) argues that "given the wavelength of the reentry, it is not the size of the heart itself that determines the pattern of room tremor (abnormal heart rhythm), but the effective size of the heart."
    , the publication also says that although the human heart is the largest, its effective size is relatively small, the closest to the effective size of the rabbit's heart.
    , the complexity of the human heart is second only to that of the brain.
    addition to the complexity of the heart itself, transplants to the 3D-printed heart are complex.
    The current method of self-transplantation at Tel Aviv University consists of three important steps: first, to obtain living adipose tissue from patients;
    to ensure optimal efficacy and safety, these processes need to be carefully scheduled, but the ongoing COVID-19 pandemic may make it difficult to sustain.
    in addition, the recurrence rate after self-transplantation is often higher than that after allogeneic surgery, but the treatment-related mortality rate is lower.
    , it's hard to print a 3D heart that can function as a contraction and pump blood, a challenge that has been a problem for a long time.
    is a key factor for the successful implantation of bioengineered tissue.
    volume of tissues larger than a few millimeters cannot survive the spread of nutrients and new blood vessels need to be formed to supply the necessary oxygen and nutrients.
    the breakthrough of bio-ink, the key cell density required for heart cells can be achieved, making them beat like normal hearts.
    , however, the long-term clinical durability of 3D printing of the human heart remains to be seen, and the specific clinical use environment is not a highly controlled laboratory environment, so the durability of clinical use remains to be seen.
    , the source of biological materials for 3D-printed hearts is important.
    many biological inks are sourced from animal or synthetic materials.
    current 3D bioprinted heart, such as BioLife4D's bioprinted heart, relies heavily on the autobiographical approach.
    this approach, bio-inks are developed using specialized heart cells obtained from patients in combination with nutrients and other materials to optimize cell survival and adapt to the bioprinting process. CollPlant Biotechnology,
    's Israeli-based regenerative and orthopaedics company, says its plant-based recombinant human collagen platform is a gold standard for tissue regeneration because it is the same type of collagen produced by the human body.
    CollPlant's bio-inks also have several benefits, including improved bio-functionality.
    's recent strategic collaborations with 3D Systems and United Therapeutics, which initially focused on lung regenerative medicine, have the potential to continue exploring 3D bioprinting of the heart and other important organs.
    long road ahead, and it's great to see the prospect of a 3D-printed human heart.
    , however, the scalability of this technology requires ready-made and sustainable sources of bio-ink to ensure access to the needy in both economically and developing countries.
    may take at least 10 years to equip a heart printer in a state-of-the-art hospital;
    the severity of cardiovascular disease, it is important to remain optimistic and ultimately address the clinical and economic complexities of a 3D-printed heart.
    .
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