3D structure diagram of mammalian cell nuclear fiber layer in the native environment.

The genetic material of the endocyst is located in the nuclei of the cell.
has a nuclear hole complex on the nucleosphere, through which genetic information flows out of the nucleosis.
under the nuclear membrane, close to the location of the nuclear hole complex has a thickness of about 14 nanometers (thin and thick, not uniform) of the nuclear fiber layer, the nuclear fiber layer is the basic component of the nuclei of the cell.
these mediated filamentous proteins form a filament network that connects the nucleofilm to chromosomes.
in addition to being responsible for stabilizing the nucleostructs, they are also involved in many other nuclear activities, such as tissue chromosomes, transcription and replication.
, however, little is known about the tissue results of the cellular nuclear fiber layer.
March 1, Nature magazine first reported on the 3D structure of the cellular nuclear fiber layer in the native environment.
Ohad Medalia, professor of cell biology and structural biology at the Department of Biochemistry at the University of Zurich in Switzerland, and his team scanned the fibroblasts of mice using cryo-electron tomography (cryo-electron tomography) to illustrate the molecular structure of the nuclear fiber layer in mammalian cells.
is a technique that combines electron microscope and X-ray fault photography.
the 3D structure of the cell's natural state before the observer's eyes.
observation, cells only need to be frozen in liquid ethane at -190 degrees C, eliminating the need for pre-treatment of other harmful chemicals, thus maximizing the original state of the cell structure.
scaffolding protein (scaffold) is involved in signal transducting, collecting signaling proteins, forming polypluar complexes, and participating in the regulation of signaling paths.
first author of the paper, Yagmur Turgay, says scaffolding proteins are meager silky structures with varying lengths that make up the nuclear fiber layer.
nuclear fiber layer protein silk is mainly composed of two proteins: type A nuclear fiber layer protein and type B nuclear fiber layer protein, both in the form of polymers to form a long stem and a spore structure, long like a hooded needle.
Through careful observation of independent nuclear fiber layer protein wire, it is found that the spter structure consists of type A nuclear fiber layer protein and type B nuclear fiber layer protein together to form a four-unit filament, the outer diameter is only 3.5 nanometers.
Compared to the cytoskeleton in the ebony (consisting of microtubes, microfilaments, intermediate fibers, microtubes with an outer diameter of about 25 nanometers and a length of several microns), the nuclear fiber layer protein filaments in the nucleus are thinner and more refined.
to bring new hope to patients with premature aging and muscular dystrophy, mutations in the nucleocleoprotein gene can lead to premature aging, muscular dystrophy, fat metabolism disorders, and neurological disorders.
"low-temperature electron fault photography" can help us compare the structural differences between normal people and patients with genetic mutations.
, a researcher at the University of New China, believes the new technology has facilitated the study of disease models at the molecular level, paving the way for new types of interventional therapy.
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