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    Home > Biochemistry News > Biotechnology News > 448 million dollars!

    448 million dollars!

    • Last Update: 2021-11-16
    • Source: Internet
    • Author: User
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    Recently, Lundbeck announced that it has reached a final agreement with AprilBio of South Korea
    .
    According to the agreement, Lingbei obtained the global exclusive rights to the research, development and commercialization of the latter's neuroimmune disease candidate drug APB-A1, which is a new and well-differentiated anti-CD40 ligand (CD40L) Antibody-like drug candidates are expected to undergo phase 1 clinical trials around the beginning of 2022

    .

    According to the terms of the license agreement, Lundbeck will pay AprilBio a one-time payment of US$16 million in cash
    .
    In addition, Lundbeck will also pay up to 432 million US dollars in successful development, supervision and sales milestones related to AprilBio and APB-A1

    .
    Lundbeck will also pay AprilBio tiered royalties, the highest tier reaching the low double-digit percentage of net sales

    .

    The press release shows that too many people around the world suffer from brain diseases-complex diseases are often invisible to others, but they have brought huge losses to individuals, families and society
    .
    Lingbei is committed to fighting against brain diseases, and advocates that the society accepts patients with brain diseases more widely

    .
    Every day, we are striving for improved treatment and a better life for patients with brain diseases

    .

    APB-A1 is a neutralizing anti-CD40L antibody-like drug candidate with an innovative molecular design that blocks the CD40L/CD40 costimulatory interaction
    .
    The activation of the CD40L/CD40 signaling cascade is critical to the initiation of cellular and humoral immune responses

    .
    It is an established and clinically proven immune pathway that can trigger the activation and differentiation of B cells, T cells and several other immune cells (such as monocytes, macrophages, dendritic cells, natural killer cells) And proliferation to mediate the immune response

    .
    Therefore, regulating the CD40L/CD40 interaction brings great hope for the treatment of various autoimmune-related central nervous system (CNS) diseases and other neurological diseases

    .

    APB-A1 is a human high-affinity anti-CD40L antibody-like fusion protein designed to inhibit the CD40L/CD40 pathway by neutralizing and activating CD40L on T cells, thereby significantly weakening the initiated immune response
    .
    In preclinical studies, APB-A1 has been confirmed to bind to CD40L, resulting in a reduction in antibody response and circulating inflammation markers

    .
    A different aspect of the design of APB-A1 is its ability to use human serum albumin to extend the half-life, which translates into superior clinical features

    .

    (The original text has been deleted)

    Reference materials:

    [1] Lundbeck receives exclusive rights to APB-A1, an innovative phase I-ready bio-therapeutic for the treatment of neuroimmune diseases from AprilBio.
    Retrieved 2021-10-16, from https://pipelinereview.
    com/index.
    php/ 2021101679431/Antibodies/Lundbeck-receives-exclusive-rights-to-APB-A1-an-innovative-phase-I-ready-bio-therapeutic-for-the-treatment-of-neuroimmune-diseases-from-AprilBio.
    html

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