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    Home > Biochemistry News > Biotechnology News > 5-Serotonin metabolism.

    5-Serotonin metabolism.

    • Last Update: 2020-10-21
    • Source: Internet
    • Author: User
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    name
    5-oxycodone (5-ydroxytryptamine 5-HT) a.k.a.
    Serum
    tensionin (serotonin), was first found in the serum. There are 5-serotonin neurons in the central nervous system, but no 5-serotonin neurons have been found in the peripheral nervous system of vertebrates.because 5-serotonin cannot pass through the blood-brain barrier, the central serotonin 5-serotonin is synthesized in the brain and is not a source of hydroxysamine in the outer week. Using
    tissue
    chemistry, it is proved that the distribution of cytosomes of 5-serotonin neurons in the brain is mainly concentrated in the middle seam nucleation group of the brain stem, and the endings are widely distributed in the brain and spinal cord.(i) synthesis, storage and release of 5-serotonin prealamide prelude is tryptophan. Tryptophan produces 5-serotonin through a two-step enzyme-called reaction, i.e. hydroxycodyme and dehydrate. This process is somewhat similar to the production of pythonamine., like tyrosine hydroxylase, requires O2, Fe, and coenzyme trichonate. However, the brain has less content and less activity, so it is a speed limit enzyme for 5-HT biosynthetics.
    addition, the concentration of 5-HT in the brain affects the activity of tryptophan hydroxylase, thus acting as a feedback self-regulating effect on 5-HT. The concentration of free tryptophan in the blood also affects the synthesis of 5-HT in the brain, and when serum free tryptophan increases (e.g. after injection of tryptophan into the abdominal cavity of
    rats
    ), the tryptophan entering the brain increases, thus accelerating the synthesis of 5-HT.(ii) Re-ingestion and degradationand cerial phenol amine delivery, released to the synapse gap of 5HT, most of the pre-synapse nerve endings re-ingested, and re-ingested, part into the vesicle re-storage, part of the Monoamine
    oxidase
    (MAO) oxidized on mitochondrial membranes:This is the main way to degrade 5-HT in the brain, and 5-hydroxyndolacetic acid (5-hydroxyindolacetic acid) is not biologically active.examination of the effects of 5-HT on various neurons, it was found that 5-HT excites most pre-intersectional neurons and inhibits pre-intersectional neurons. Damaged animals' mid-seam nuclei or drugs blocking 5-HT synthesis can significantly reduce the level of 5-HT in the brain, and cause sleep disorders in animals, lower pain thresholds, while morphine analgesic effects also weaken or disappear.
    if the electrostatus stimulates the middle seam nucleus of the rat, it can affect their body temperature increase, on the other hand, the 5-HT update in the rat's brain is also observed to accelerate as room temperature rises. These phenomena reveal a relationship between 5-HT in the brain and sleep, analgesy, and thermodysmodysmodys. It has also been reported that 5-HT can alter the endocrine
    endocrine
    pituitary gland. In addition, it has been suggested that the destruction of neurons with 5-HT energy is the cause of hallucinations in mental illness. It can be seen that mental activity also has a certain relationship with 5HT.
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