651 new crown patients discharged from hospital follow-up in Wuhan: 3% "Fuyang"

the new crown outbreak lasted more than half a year, around the virus itself and clinical problems are still to be solved, "Fuyang" is one of the concerns. On July 6, local time, a team of researchers from Huazhong University of Science and Technology, Wuhan Lung Hospital Respiratory Critical Medicine, and the University of Munich in Germany published an opinion article in the top medical journal Lancet Infectious Diseases, "Assessment of Patients Testing for COVID-19 after recovery", which disclosed the follow-up of 651 patients discharged from Wuhan's new crown.
from January 11, 2020 to April 1, 2020, 651 patients recovered at Wuhan Lung Hospital. All discharged patients were followed by two medical teams, with a medium follow-up time of 48 days (IQR 18-50) and a maximum follow-up time of 91 days. During the follow-up process, 651 patients were retrouted with RT-qPCR for SARS-CoV-2 and 23 cases (3%) were found to be positive, known as yin and yang.
age of 56.0 years (range 27.0-89.0, IQR 48.5-74.0) was 56.0 years in the retest-positive group, slightly more female (12 cases, 52 per cent) than males (11 cases, 48 per cent). In the retR positive group, 12 patients (52%) had moderate symptoms during the previous period of hospitalization, 9 patients (39%) were severe, and 2 patients (9%) were critically ill.
time from discharge to retration was 15.0 days (range 4-38, IQR 11.0-16.5). The mid-time time from re-testing positive to re-entry is 1.5 days (IQR 1.0-2.0).
the follow-up medical team tested positive for anti-SARS-CoV-2 virus immunity
, which showed that 7 patients (30%) IgM and IgG were positive, 5 patients (22%) were positive but IgM was negative, and the remaining 11 patients (48%) were negative.
in the retration-positive group, 15 patients (65%) were asymptomatic at the time of the ret examination, while the remaining 8 patients (35%) had at least one symptom associated with COVID-19. Specifically, there were 6 cases of fever (26%), 2 cases of cough (9%), 1 case (4%) of fatigue, 1 case (4%) of breathing difficulties and 1 case (4%) of chest tightness.
authors note that while a positive PCR test for asymptomatic patients may only reflect residual non-pathogenic viral components, a symptomatic patient's review of positive indicates the likelihood of recurrence and transmission of active disease.
the last follow-up visit was on 4 April 2020, when all 23 re-diagnosed positive patients survived, 18 (78%) were discharged, 4 (17%) continued to be hospitalized and 1 (4%) remained at home in self-isolation. One of the 80-year-old patients had suicidal thoughts.
authors believe that these patients who tested positive for the virus did not cause new transmission. This may be due to precautionary measures taken by the hospital to take the patient to a temporary hospital or other relevant health centre for 14 days of clinical monitoring.
the authors also mentioned other cases of discharged patients. In this follow-up study, 3 discharged patients failed to participate in the ret examination, of which 2 died (1 case with coronary heart disease and 1 case of acute respiratory distress syndrome) and 3 died of cardiac arrest. In addition, in patients who were negative for ret examination, one patient required amputation due to thrombosis in the legs.
"We found that 52 percent of patients who tested positive for the drug carried antiviral IgG antibodies and 30 percent carried IgM antibodies, suggesting that their immune systems produced partial immune recognition," the authors concluded. However, since 35% of patients who retr tested positive showed one or more COVID-19-related symptoms, the role of antibodies in COVID-19 removal is still in doubt, and the possibility of further transmission of the virus after discharge from hospital is worth further investigation. In
to prevent the second wave of infection with neo-crown pneumonia, the authors recommend that patients with neo-crown pneumonia should be clinically observed for at least 14 days at a medical facility such as Fang Cockpit after recovery.
it's worth noting that for patients with "fuyang" that are reported around the world, the authors note, "it's still not clear why patients test positive again." "Previously, some researchers believed that the "fuyang" of the new crown patients or the "false negative" problem of the test results when discharged from the hospital.
China
, Army Medical University Professor Yu Xiuwu, Chinese People's Liberation Army Third Military Medical University Professor Liu Xindong and others previously published on April 28 in a new crown death of the pathology study also showed that a three consecutive new coronary nucleic acid test negative, meet the discharge criteria of patients died of heart disease accident. The researchers conducted a pathological study of the remains and, by seping tissue from the lungs, liver, heart, intestines and skin, found that there was still a new coronavirus in the lungs.
, Qin Chuan of the Chinese Institute of Medical
Medical Animal Experiments and others using a model of rhesus monkeys infected with SARS-CoV-2, suggests that primary neo-coronavirus infection can prevent subsequent re-infection.