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    Home > Active Ingredient News > Endocrine System > 66 indicators are abnormal! Focus on the "metabolic disorders" after thyroidectomy | 2022ATA

    66 indicators are abnormal! Focus on the "metabolic disorders" after thyroidectomy | 2022ATA

    • Last Update: 2022-11-01
    • Source: Internet
    • Author: User
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    Introduction: Evidence suggests that metabolic disorders (e.
    g.
    , hormonal disturbances, physical fatigue, etc.
    ) occur after papillary thyroid carcinoma (PTC) resection, even after which the patient is treated with thyrotropin (TSH) suppression
    .
    However, the specific metabolomic characteristics of patients after surgery are not clear
    .


    Recently, a study published at the 2022 American Thyroid Association Annual Meeting (2022ATA) confirmed that patients after thyroidectomy still have significant metabolic disorders after thyrotropin suppressive therapy, and the study observed an increase
    in the level of 66 lipid-related metabolites.


    Exploration: Metabolomic features after thyroidectomy


    To understand the metabolomic profile after thyroidectomy, 50 patients with PTC without metabolic disease were included in the study, with the same
    number of patients who underwent either full (T) or unilateral (L) thyroidectomy.
    Patient clinical features and fasting serum samples
    were collected before surgery (T0) and 1 month after surgery (T1).
    Serum metabolome characterization
    was detected by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS).


    Postoperative lipid metabolite indicators increased


    The results were compared, before and after surgery, and the characteristics
    of patient metabolism between different procedures.


    Compared with the T0 group, the metabolomics in the T1 group was significantly
    different.
    Levels of 66 lipid-associated metabolites increased and levels of one nucleotide metabolite decreased (OPLS-DAVIP>2.
    0), while TSH levels did not change
    significantly.


    Among these metabolites, lipids such as long- and short-chain fatty acids account for the vast majority, which also represents a significant change in
    β-oxidation and omega-oxidation levels.


    Comparison of results between different surgical modalities showed that the main difference between the T and L groups was the secondary bile acid metabolism and the different
    levels of benzoic acid metabolism.


    Summary of this article


    The results of the study confirmed that patients with PTC who recovered with TSH suppression had metabolic disorders, indicating that levothyroxine does not completely compensate for impaired thyroid function
    .
    Therefore, clinical attention should be paid to postoperative metabolic disorders and long-term quality of life
    in PTC patients.


    REFERENCE: LONG‐TERM MORTALITY AND CARDIOMETABOLIC EFFECTS OF TREATMENT FOR HYPERTHYROIDISM: EGRET STUDY.
    THYROID

    Volume 32, Supplement 1,2022.
    https://doi.
    org/10.
    1089/thy.
    2022.
    29140.
    lb.
    abstracts

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