A 10-d'amin breaker vitamin C - inhibits chronic stress leading to tumor stem cells!

cancer is a word that makes people feel scared and anxious. As a result, many women with cancer and treatment experience chronic stress and depression. Scientists have found in experiments in humans and rodents that stress accelerates cancer progression, but it's not clear what mechanisms are behind it.
A recent study published in Journal of Clinical Investigation by Dalian Medical University, Sun Yat-sen University and others revealed the secret: the stress hormone epinephrine triggered a series of biochemical reactions that led to the growth and metastasis of cancer cells.
the study, researchers first demonstrated the effects of chronic stress on the growth of cancerous stem cells, something previous studies have not looked at. Using a mouse model of immunodeficiency, the researchers found that chronic stress-induced epinephrine promotes the production of cancer stem cell-like properties in breast cancer cells, mainly by resetting the metabolic pathways that rely on lactate dehydrogenase (ALDHA).
chronic stress-induced epinephrine activates LDHA to produce lactic acid, which alters pH, which causes the detoxification of USP28-mediated MYC to enhance its stability. THESS enhancer is then activated by MYC, which causes cancer cells to produce breast cancer stem cell-like properties.
drug screening tests targeting LDHA, the researchers found that vitamin C can reverse a stem cell-like trait induced by chronic stress. These findings demonstrate the importance of physiological factors in promoting the properties of stem cell-like cells in breast cancer cells. Therefore, vitamin C, which inhibits LDHA, may be an effective drug against stress-related breast cancer. (Bio Valley)