A 12-year follow-up study of 410,000 people: Genetic factors + unhealthy lifestyle can increase the risk of gout by up to 200%!

Gout is caused by the deposition of sodium urate crystals in the joints after prolonged hyperuricemia

Gout is caused by the deposition of sodium urate crystals in the joints after prolonged hyperuricemia

Despite advances in understanding the pathophysiology of gout and increased availability of effective urate-lowering therapies, clinical management of gout remains suboptimal

It is well known that both genetic and life>

It is well known that both genetic and life>

There is growing evidence that life>

Within the UK Biobank, 416,481 gout-free participants (aged 37-74 years) were identified at baseline

Within the UK Biobank, 416,481 gout-free participants (aged 37-74 years) were identified at baseline

Of the 416,481 study participants, 191,234 (45.

In a multi-adjusted Cox regression model, the HR and 95% CI for gout was 1.

In a multi-adjusted Cox regression model, each of the four life>

In a multi-adjusted Cox regression model, each of the four life>

In further analysis, the risk of gout decreased significantly with each increment of healthy life>

Figure 1 shows the relationship between gout and combined exposure to life>

Kaplan-Meier survival curves showed that the risk of developing gout was highest for people with high genetic susceptibility and an unfavorable life>

Kaplan-Meier survival curves showed that the risk of developing gout was highest for people with high genetic susceptibility and an unfavorable life>

Combined influence of life>according to cardiometabolic disease ( CMD) status

Combined influence of life>according to cardiometabolic disease ( CMD ) status

It was investigated whether the association between gout risk and combined exposure of life>
.
The incidence of gout per 1000 person-years was 1.
35 (95% CI: 1.
13-1.
51) for participants with high genetic susceptibility and poor life>
.
In addition, the researchers observed a significant doubling ( P  =0.
001) and additive interaction (RERI: 2.
211, 95% CI: 1.
282-3.
141) between CMDs and the combined exposure of life>
.

It was investigated whether the association between gout risk and combined exposure of life>
.
The incidence of gout per 1000 person-years was 1.
35 (95% CI: 1.
13-1.
51) for participants with high genetic susceptibility and poor life>
.
In addition, the researchers observed a significant doubling ( P  =0.
001) and additive interaction (RERI: 2.
211, 95% CI: 1.
282-3.
141) between CMDs and the combined exposure of life>
.
P

In this large population-based prospective cohort study, researchers found

In this large population-based prospective cohort study, researchers found

(1) Genetic factors are associated with a higher risk of gout,

(1) Genetic factors are associated with a higher risk of gout,

(2) A healthy life>

(2) A healthy life>

(3) people with moderate to high genetic susceptibility can reduce the risk of gout by adopting a favorable life>

(3) people with moderate to high genetic susceptibility can reduce the risk of gout by adopting a favorable life>

(4) The relationship between gout and combined exposure of life>
.

(4) The relationship between gout and combined exposure of life>
.

In conclusion, genetic susceptibility and unhealthy life>
.
However, a healthy life>
.
The findings of this study underscore the importance of maintaining a healthy life>
.

In conclusion, genetic susceptibility and unhealthy life>
.
However, a healthy life>
.
The findings of this study underscore the importance of maintaining a healthy life>
.

 

Original source:

Original source:

Zhang Y, Yang R, Dove A, et al.
Healthy life>BMC Med .
2022;20(1):138.
Published 2022 Apr 29.
doi: 10.
1186/s12916-022-02341-0

Zhang Y, Yang R, Dove A, et al.
Healthy life>BMC Med .
2022;20(1):138.
Published 2022 Apr 29.
doi:10.
1186/s12916-022-02341-0 BMC Med

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