A 30-year long-term follow-up study of high intake of folic acid in youth may reduce the risk of diabetes.

Previous studies have found that high homocysteineemia associated with insulin resistance (IR) is one of the risk factors for T2DM, and that it is mostly caused by genetic defects, renal insemination or inadequate intake of vitamins such as folic acid.
have also reported in randomized clinical trials that folic acid supplementation improves IR and lowers levels of inflammatory media.
this leads to speculation that vitamins such as folic acid may have a beneficial effect on the risk and treatment of T2DM.
On July 31, 2020, researchers from Columbia University's Irvine Medical Center and Texas State University published a new study on the association between folic acid and vitamin intake and diabetes in Diabetes Care, a top journal on diabetes, and found a negative correlation between folic acid and vitamin B6 intake and the prevalence of diabetes, possibly due to folic acid's involvement in regulating high cysteine levels, insulin sensitivity and systemic inflammation.
researchers recruited a total of 4,704 participants between the ages of 18 and 30 without diabetes from four different locations in the United States, with 52 percent of women.
followed them for up to 30 years, during which they assessed folic acid and vitamin B6 and B12 intake through dietary surveys and counted information on covariates such as height, weight, smoking status, and family diabetes history. in addition to
, participants' glucose, insulin, glycoglobin HbA1c, inflammatory markers, blood-like cysteine Hcy, anteater blood sugar and non-empty blood sugar were regularly measured to assess the correlation between vitamin intake such as folic acid and diabetes, inflammation, etc.
follow-up period, a total of 655 cases of diabetes occurred.
According to the distribution of vitamin B intake of participants, the relationship between vitamin B intake and diabetes incidence was analyzed using Cox proportional risk regression model, and it was found that folic acid intake was negatively related to the incidence of diabetes.
B6 intake was also significantly negatively associated with the incidence of diabetes, with a risk ratio of 0.64 for the highest 1,000th bit.
B12 intake was not significantly associated with the prevalence of diabetes.
The multivariate adjustment between HRs folic acid intake levels and the incidence of diabetes in the
B vitamin intake five-part diabetes adjustment HRs In order to explore the potential mechanisms for the beneficial effects of folic acid intake on diabetes, the researchers analyzed folic acid intake and serum Hcy, I The relationship between R biomarkers (peritition blood sugar levels, insulin levels, insulin resistance score (HOMA-IR) and islet beta cell function index (HOMA-b), and systemic inflammation (CRP, fibrinogen and IL-6).
results showed a significant negative correlation between folic acid intake and Hcy and insulin levels, inversely inversely compared to CRP concentration, and inverse correlation with contrainceited blood sugar, HOMA-IR, HOMA-b, fibrinogen and IL-6 levels.
the negative correlation between folic acid and the risk of diabetes may be explained by the insulin sensitivity of folic acid, promoting Hcy metabolism or participating in the regulation of inflammation.
Floric acid intake and the multivariate adjustment MDs of homocysteine, insulin, and CRP in short, the study found that increasing folic acid intake over a 30-year period significantly reduced the risk of diabetes and explored its potential mechanisms of action.
this discovery provides a new diabetes prevention strategy, for health, remember to eat more fruits and vegetables rich in folic acid and vitamin B Oh!