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    Home > Medical News > Latest Medical News > A 3D imaging microscope can observe living cells

    A 3D imaging microscope can observe living cells

    • Last Update: 2020-11-28
    • Source: Internet
    • Author: User
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    , June 30 (Xinhua Mao Li) According to local media reports, Israel University of Technology has successfully developed a new type of microscope that can display three-dimensional images of living cells at ultra-high resolution, which is expected to revolutionized biological research.
    , biologists use two-dimensional images of cells presented by a microscope to observe their internal conditions, and the cells themselves are three-dimensional structures, so two-dimensional images undoubtedly lose some of their information.
    , people have been scanning study samples layer by layer and then using computers to synthesize 3D graphics to understand the structure of objects. However, the layer-by-layer scanning process requires that the scanned object remain stationary throughout the process, a limitation that suggests that it is unlikely to be used to observe living cells. The standard optical microscope has limitations because of the lens diffraction limit.
    ultra-resolution 3D imaging system, called DeepSTORM3D, developed by researchers at israel's Polytechnic University, not only maps at 10 times the resolution of a standard optical microscope, but also creates dynamic 3D images of the subjects.
    Professor Joav Shortman, head of system development at DeepSTORM3D, said depth information can be obtained from the two-bit image by the waveform forming method, which encodes the depth of each molecule in the image obtained by the camera. The problem, however, is that if there are multiple molecules nearby, their images overlap in the camera image, which greatly reduces spatial and time resolution, so that sometimes it is not possible to obtain useful images for some of the subjects.
    to solve this problem, researchers are turning to deep learning to develop an artificial neural network that can produce its own solutions. After training the system by inputing a large number of virtual samples into the network, the neural network knows how to produce ultra-high-resolution 3D images from real-world microscope data.
    using the system to map three-dimensional images of the mitochondrials, the cell's energy-producing body, and to image fluorescently labeled telomeres in living cells. Mr Shortman said the new technology, which maps biological processes in living cells at ultra-high resolution, would help expand the depth of biological research.
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