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An observational study recently published online in the British Journal of Ophthalmology suggests that a caffeine metabolite called 7-methylxanthine ("7-MX") may slow the progression
With the acceleration of the iteration speed of various electronic product updates, its use has penetrated into all corners of people's lives, followed by the continuous growth
About 30% of people worldwide are myopic, and this number is expected to grow to 50% by 2050, with about 10% of them reaching a high degree of myopia above 500 degrees
It should be noted that the development of myopia in China in recent years has shown a high incidence, young age and severe trend
It is worth mentioning that once high myopia is formed, it may lead to serious and irreversible blinding changes, refractive correction of high myopia and treatment of its complications are expensive and ineffective, which is why controlling the growth of the eye axis and improving the state of the sclera are the focus of current myopia research [2].
The caffeine metabolite 7-MX can inhibit the growth of the human eye axis, which in turn plays a role in slowing the progression of myopia
Figure 1 Research results (Source: [3])
Myopia not only causes vision loss, but is also associated with an increased risk of various diseases that affect eye health, such as macular degeneration, cataracts, glaucoma, and retinal detachment
In the study, the researchers used a linear mixed model to analyze longitudinal ciliary muscle paralysis diopter and eye axis length data
The average follow-up time for these children was 3.
An average increase of 1.
A 11-year-old who took 1000 mg of 7-MX per day had a progression rate of 1.
Fig.
The model in the study predicted that children who took 1000 mg per day had an eye axis length reduction of about 0.
But the study also has limitations
We are looking forward to the control of the progression of myopia by the caffeine metabolite 7-MX and hope that the causal relationship between the two can be demonstrated in a wider range of randomized controlled trials
