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    Home > Biochemistry News > Biotechnology News > A certain protein causes deadly cancer

    A certain protein causes deadly cancer

    • Last Update: 2022-09-08
    • Source: Internet
    • Author: User
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    A discovery led by the University of California, Irvine has propelled the search for improved treatments


    The GLI1 protein, the subject of this study, is critical for cell development but is also implicated in some cancers


    "In some cases, a protein in one pathway can turn on a protein in another pathway," said A.


    GLI1 normally forms strong bonds with a protein called SUFU


    "We identified three that can be phosphorylated and involved in weakening the binding between GLI1 and SUFU," said Lee Bardwell, a professor of developmental and cell biology whose lab conducted the project


    He noted that phosphorylation at all three sites resulted in significantly higher levels of GLI1 escaping from SUFU compared to just one or two accepting phosphate groups


    The discovery is an important step toward more effective and personalized cancer treatment


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