A fluoroallylation reaction of difluoroethylene under visible light was reported by Feng Chao, Professor of Nanjing University of Technology

According to incomplete statistics, at present, 20% of medicines and 30% of pesticides contain at least one fluorine atom Fluorinated compounds play an increasingly important role in life science, material chemistry, national defense industry and other fields Therefore, in recent decades, fluorine chemistry has been developed unprecedentedly Many methods of introducing fluorine atoms into compounds have been reported Because of the unique physical and chemical properties of trifluoromethyl, the introduction of trifluoromethyl into organic molecules can significantly change its electrical, solubility, lipophilic and other properties However, most of the reported methods of trifluoromethylation focus on the introduction of trifluoromethyl into aromatic rings However, the method of constructing the structure of benzyl trifluoromethyl tertiary carbon / quaternary carbon is limited Therefore, it is still of great significance to develop a clean and efficient method to construct benzyl trifluoromethyl tertiary carbon / quaternary carbon center structure Recently, Professor Feng Chao's research group of Nanjing University of Technology reported a fluoroallylation reaction of difluoroethylene under visible light In this method, the excited state photocatalyst is used to oxidize the two fluorine olefins The realization of this process induces and promotes the subsequent nucleophilic addition of fluorine ions Then, the electron transfer process in the molecule is followed to obtain α - three fluorine methylbenzyl radical The free radicals are added with allylsulfone to eliminate the free radicals of one molecule phenylsulfone At the same time, the photocatalyst in the redox state of phenylsulfone radical makes it return to the ground state and continue to participate in the new catalytic cycle The basic body of sulfone is reduced to sulfone anion The reaction conditions are mild, showing good compatibility and selectivity for different functional groups, and has broad application prospects Relevant work was published in angel Chem Int ed (DOI: 10.1002 / anie 201814308) under the title of "Photoredox combined f-nuclear addition: Alliance of Gem - difluoroalkenes" The first author of this work is Liu Haidong, a doctoral candidate in the school of chemistry and Molecular Engineering (IAS) of Nanjing University of technology, and the corresponding author is Professor Feng Chao, School of chemistry and Molecular Engineering (IAS).