A gene was found in a high-fat diet that prevents excessive weight gain and diabetes

Obesity and diabetes are increasingly serious international problems in recent years

In 2019, 463 million people worldwide were diagnosed with diabetes, and 374 million people were at risk of developing type 2 diabetes

Researchers suspect that the gene that causes diabetes is Negr1

In the experiment, mice of both sexes were used, which has never been done in previous similar studies

In the glucose tolerance test, the glucose tolerance of mice without Negr1 was much lower than that of mice with Negr1, and they reached a pre-diabetic state

Since Negr1 promotes depression and schizophrenia, its effect on body weight has so far been considered a side effect of mental disorders

There is still no reason to despair

In summary, it can be said that NEGR1 protein affects body weight, appetite and mental health, including the development of diabetes and mental illness

Original search:

High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice

DOI

10.