A genetic mutation on chromosome 6 will increase the risk of five vascular diseases.

July 28 (Xinhua) -- A genetic mutation on human chromosome 6 can increase the risk of five vascular diseases, including coronary heart disease, U.S., Dutch and German scientists report in a new issue of the American journal Cell.
discovery will help develop new approaches to these diseases.
previous study found that mutations in a region on chromosome 6 were associated with five vascular diseases, including coronary heart disease, migraines, high blood pressure, neck artery mezzanine and fibromyal dysplitis.
new study identified specific genetic codes and found why it increases the risk of vascular disease.
researchers at Harvard University and other institutions analyzed information about hundreds of thousands of people and found this core mutation.
it is a change in the "letters" of a single nucleotide in the DNA (deoxyrigenation) code, located in a non-coding area.
these areas do not guide protein synthesis, but regulate gene activity.
DNA consists of four DNA nucleotides, namely adenine, thymus, cytosine, and ostrich, represented by the letters A, T, C, and G.
that this core mutation affects the expression of the EDN1 gene in the "downstream" region of chromosomes.
if the nucleotide "letter" in the site becomes G (Bird's Den), the EDN1 gene will become more active and secrete more endotinopid 1 protein.
endopilatin1 is a powerful, long-acting vasotrostrient that causes plaques and hardening of the inner walls of the arteries, increasing the risk of disease.
is far from the EDN1 gene, but the activity is closely related, which is another example of gene long-distance regulation.
.