A map of cellular characteristics of multi-cancer endocysts was revealed

Project Design and Key Conclusions
On February 5, Zhang Zemin Of Peking University's Center for Frontier Innovation in Biomedical Science and the Beijing Future Center for High-Sharp Innovation in Future Genetic Diagnostics, in cooperation with the Beijing University Cancer Hospital's Step-By-Step De Task Force and Ji Jiafu's Research Group, published a research paper in the journal Cell. In the single-cell level, the study systematically depicted tumor-immersed myelin cells in 15 cancerous species, compared the characteristics of fat cells, degenerative cells and tumor-related macrophages in different cancer species, and provided an important basis for immunotherapy targeting endoblast cells in different cancer species.
" this study, for the first time, used pan-cancer analysis to map the characteristics of tumor-immersed myelin cells in different cancer species, and systematically compared the differences in composition and function of various myelin cell groups within different cancer species. Zhang Zemin, one of the authors of the communication, told China Science Daily.
believes that this pioneering international work could provide new ideas for further study of the functional effects of myelin cell groups and the development of new immunotherapy targeting myelin cells. The research provides a new way of thinking for immunotherapy targeting hypertrophic cells in nasopharyngeal cancer, provides a basis for the potential source of LAMP3
dexterous cells and their function in tumor immunity, and lays the foundation for the subsequent development of immunotherapy specific to target tumor-related macrophages in different cancer species.
researchers have three main findings. The first is that fat cells show different functional states in multiple cancerous species, the second is that the activated LAMP3
dendrogen cells are widely present in a variety of tumors, and the third is that tumor-related macrophages are highly heterogeneous in different cancerous species.
tumors have complex ecosystems. Cancer cells form complex cell control networks by interacting with many other types of cells, such as immune cells. In addition to lymphocytes, myelin cells are also an important component of tumor-immersed immune cells, which play an important role in regulating tumor inflammatory response and angiogenesic, and thus become another popular target cell for cancer treatment in clinical research.
Although single-cell transcription group sequencing techniques have been widely used to characterize tumor-immersed immune cells and to identify new myelin cell groups within specific cancer species, it is still unknown whether these newly identified myelin cell groups are widespread within various types of tumors.
Thus, by integrating the single-cell transcription group sequencing data produced by the laboratory itself and published public data, the researchers constructed a map of myelin cells in 15 cancer species and systematically compared the differences in composition, development and function of myelin cell groups among different cancer species.
After comparing the distribution and functional characteristics of various myelin cell groups in different cancerous species, the researchers found that the proportion of TNF-/VEGFA-cells in fat cells soaked in nasopharyngeal cancer tumors was significantly higher than in other cancerous species, suggesting that the fat cells soaked in nasopharyngeal cancer tumors may have stronger anti-tumor properties, and the corresponding clinical survival analysis further supports this conclusion.
, through a network analysis of intercellular interactions, the researchers speculated that the rich IL1B-macrophages within nasopharyngeal cancer tumors could induce the anti-tumor properties of hypertrophic cells through the interaction between IL1B-ADRB2.
researchers found that a new class of mature FORM LAMP3-plus dextrophic cells previously reported in liver cancer tumors is widely present in 15 cancer species, and that such cells can further detail their transcription group characteristics based on their developmental origin.
by comparing the similarities between sub-group composition and transcription groups of myelin cells in different cancer species, the researchers found that macrophages showed a high degree of heterogeneity within different cancerous tumors. In particular, although there are angiogenesic macrophage groups associated with poor prognostication in tumor patients in different types of cancer, different characteristic marker genes are present in different cancer species. This result suggests that immunotherapy options targeting tumor-related macrophages in particular need to consider their transcriptional specificity in different cancer species. (Source: Cui Xueqin, China Science Daily)
related paper information: