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A paper published online October 31 in the British journal Nature Method describes a way to visualize four cell cycles simultaneously in living cells using a new fluorescent protein.
this technique can help improve the characteristics of cell cycles and their regulation, and improve understanding of developmental biology and cancer formation.
life of cells is a continuously updated, continuous start-up process.
begins with the division of its parent cells and ends with the formation of its daughter cells or the death of the cells themselves.
cell cycle is the process that begins with one cell division to form a child cell and ends with the next cell division to form a child cell.
cells circulate between stages such as pre-stage, growth, DNA replication, and division.
has always been difficult to distinguish between the four stages of cells, because it is technically difficult to image signals from many different reported proteins (proteins that act as reported genes) at the same time.
To overcome this limitation, Michael Lin and colleagues at Stanford University in the United States developed a fluorescent protein called mMaroon1, which is located at the far red end of the visible spectrum and can be imaged with both cyan, green and orange fluorescent proteins.
team used this far-red reporting protein to mark a protein that marked a transition period between phase S (DNA replication) and stage G2 (cell growth), thus distinguishing all stages of the cell cycle, wherease the previous system could only simply distinguish between three of the four stages.
2011, scientists won the Nobel Prize in Physiology or Medicine for their "discovery of key molecular mechanisms in cell cycles."
the researchers' ability to properly regulate cell cycles is critical to understanding normal physiological function, and a deeper understanding of the problems in cell cycle regulation can provide important insights into why some cells become cancerous.
the future, this knowledge may advance the field of cancer treatment and provide an important scientific basis for innovative ways of treating cancer.
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