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Recently, Paula T.
——Excerpt from the article chapter
【Ref: Straehla JP, et al.
Research background
The blood-brain barrier (BBB) is an obstacle to drug transport for the treatment of high-grade gliomas, and current understanding of the mechanisms involved in drug transport through the blood-brain barrier remains limited
Research methodology
The authors first constructed the microvascular network model of the blood-brain barrier of glioblastoma (BBB-GBM) by means of tumor spheroid culture and three-dimensional vascular mesh culture, and then evaluated the relevant characteristics and efficacy
Research results
The results of the study showed that the model was cultured to embed GBM tumor balls from patients with xenografts and cell lines in the BBB vasculature system, and induced pluripotent stem cell-derived vascular endothelial cells (iPS-ECs)/perimeter cells (PCs) and astrocytes (ACs) to self-assemble into perfusible microvessel network systems, similarConclusions of the study
In summary, the predictive microfluidic model developed by the researchers provides a reliable in vitro simulation evaluation model