echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Antitumor Therapy > A microfluidic model for evaluating BBB penetration for GBM

    A microfluidic model for evaluating BBB penetration for GBM

    • Last Update: 2022-09-21
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Recently, Paula T.



    ——Excerpt from the article chapter


    【Ref: Straehla JP, et al.



    Research background

    The blood-brain barrier (BBB) is an obstacle to drug transport for the treatment of high-grade gliomas, and current understanding of the mechanisms involved in drug transport through the blood-brain barrier remains limited



    Research methodology


    The authors first constructed the microvascular network model of the blood-brain barrier of glioblastoma (BBB-GBM) by means of tumor spheroid culture and three-dimensional vascular mesh culture, and then evaluated the relevant characteristics and efficacy


    Research results

    The results of the study showed that the model was cultured to embed GBM tumor balls from patients with xenografts and cell lines in the BBB vasculature system, and induced pluripotent stem cell-derived vascular endothelial cells (iPS-ECs)/perimeter cells (PCs) and astrocytes (ACs) to self-assemble into perfusible microvessel network systems, similar



    Conclusions of the study


    In summary, the predictive microfluidic model developed by the researchers provides a reliable in vitro simulation evaluation model



    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.