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A new approach to optimize dendritic cell tumor immunotherapy

 Last Update: 2021-10-20
 Source: Internet
 Author: User

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Dendritic cells are the main antigen-presenting cells in the immune system and are essential for "initiating" the immune response to fight infection sources and tumors

"We found that these integrin-mediated interactions inhibit the function of dendritic cells and their migration

Importantly, the researchers found that when integrins are turned off, dendritic cells start a gene expression program that allows them to better regulate T cell activation and tumor rejection

This study revealed that β-2 integrin acts as a negative regulator of dendritic cell programming

Carla Guenther, Imrul Faisal, Manlio Fusciello, Maria Sokolova, Heidi Harjunpää, Mette Ilander, Robert Tallberg, Maria Kristina Vartiainen, Ronen Alon, Jose-Maria Gonzalez-Granado, Vincenzo Cerullo, Susanna Carola Fagerholm.

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