A new conforming factor DNA has inherent curvature.

Mutations are the fundamental source of genetic diversity and play a vital role in the evolution process. The determination of
mutation rate and the identification of the conformal and transregulatory factors have always been the key issues in the field of evolutionary genetics.
may play a more important role in regulating local mutation rates compared to trans factors that have been widely identified.
unfortunate, the study of the shun factor of regulatory mutation rate is still scarce -- the study of the shun factor over the past few decades has focused on the nucleotide sequence adjacent to the mutation site.
whether there are other shun factors that can affect mutation rates remains unclear.
, in collaboration with Qian Wenfeng Research Group of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, he and Lucas B. Carey, a professor at Pompeu Fabra University, worked together to construct the mutation landscape characteristics of the high density of the yeast gene URA3 and analyze the relationship between DNA characteristics and mutation rates, and to identify a new normal factor DNA inherent curvature - the degree of Axial deviation of DNA due to the interaction of adjacent base pairs - the ability to regulate local mutation sepsis.
the natural curvature of DNA is reduced by 10%, the mutation rate can increase by 70%.
experimental data on yeast mutation accumulation strains, mutation data on genes associated with human Mendel's genetic disease, and data from the Cancer Genome Atlas, show that mutation stakes occur in areas with low inherent curvature in DNA. Further research
found that the inherent curvature of DNA did not affect the mismatch repair efficiency of the surrounding sequence, but was significantly related to the sensitivity of the mutagenesis.
thus, DNA inherent curvature may reduce mutation rates by promoting DNA sequences to bind to proteins, reducing DNA exposure to environmental mutagenics (figure).
the results of this study not only set up a new theoretical framework for understanding the local mutation rate of shun factor regulation, but also provide new insights for genomic evolution and tumor generation.
graph: DNA inherent curvature regulates local mutation rate.
(A) a diagram of the mechanism by which the inherent curvature of the
(A) DNA reduces the mutation rate mechanism.
(B) DNA inherent curvature inhibits mutagemininduced by mutagenic agents in all cancer and tumor types common (C?gt;T) and lung cancer-specific (C-gt;A).
the above-mentioned study was published in Genome Biology (DOI: 10.1186/s13059-018-1525-y).
Dr. Duan Chaorui of Qian Wenfeng Research Group, Assistant Researcher Yu Qing and Dr. Chen Xiaoxuan of Zhongshan University were co-authors of the thesis.
the study was funded by the National Natural Science Foundation of China.
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