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A new evolutionary mechanism for the accumulation of beneficial mutations in vegetative fungi revealed |
The beneficial mutation mechanism of Verticillium dahliae accumulating in agricultural ecosystems.
Photo courtesy of the Institute of Plant Protection, Chinese Academy of Agricultural Sciences
Photo courtesy of Institute of Plant Protection, Chinese Academy of Agricultural Sciences.
Beneficial mutation mechanism of Verticillium dahliae accumulation in agricultural ecosystems .
Image courtesy of Plant Protection Institute of Chinese Academy of Agricultural Sciences.
On June 25, "BMC Biology" published online the latest research results of the Crop Verticillium Wilt Prevention and Control Innovation Team of the Institute of Plant Protection, Chinese Academy of Agricultural Sciences
.
They revealed a new mechanism by which the asexually propagated Verticillium dahlia accumulates genetic variation in the agricultural ecosystem
.
Researcher Dai Xiaofeng, the co-corresponding author of the paper, introduced that Verticillium dahliae is a devastating soil-borne vascular pathogenic fungus, which is prevalent and spread all over the world, harming important economic crops such as cotton, potatoes, eggplants, and sunflowers
.
It is generally believed that Verticillium dahliae, as a typical asexual reproduction fungus, reproduces progeny mainly by replication, and the frequency of genetic mutation in the progeny population is very low
.
However, the team found through a large number of pathogenic studies in the early stage that Verticillium dahlia has the characteristics of accumulating beneficial mutations to adapt to the host.
The evolutionary mechanism of this vegetative fungus accumulating beneficial mutations and eliminating harmful mutations is still unclear
The research first established a closed agricultural ecosystem.
Through genome comparison analysis, it is found that the recovered progeny population has accumulated 2769 single nucleotide mutations and 750 short insertion/deletion mutations relative to the reference genome, forming 20 major genetic variation hotspots and reverse transcription with long terminal repeats.
What’s interesting is that Verticillium dahlia adopts the strategy of “wide entry and strict exit” to screen and accumulate beneficial genetic variation.
The study also found that these genetic variations caused 378 genes with mutations in the coding sequence and 604 genes with mutations in the promoter region, which mainly affected signal transduction functions such as transcription factors and protein kinases
This study discovered for the first time a new evolutionary mechanism of asexually reproduced Verticillium dahliae through Gypsy transposon to stimulate and select beneficial genetic mutations under the selection of resistant hosts, which is a research and prevention target for the genetic variation mechanism of the pathogen of Verticillium wilt in crops.
The research was funded by the National Key Research and Development Program of International Cooperation in Science and Technology Innovation, the National Natural Science Foundation of China, and the Science and Technology Innovation Project of the Chinese Academy of Agricultural Sciences
Related paper information: https://doi.
https://doi.