A new function of the neuroendocrine hormone SN in neurovascular development.

The neuroendocrine factor Secretoneurin (SN) is formed by the protein hydrolysis of the secretion granunoprotein II (Fedorgranin II, Sg II) and is very conservative in vertebrates such as fish and mammals (including humans).
recent studies have found that SN has endocrine, neuroendocrine, side secretion and self-secretion activity, especially the secretion of lutein,hormone LH, an important signaling molecule that significantly stimulates the reproductive axis of vertebrates.
, the idea that SN is a new neuroendocrine hormone has been recognized by international peers, according to Vance L. Trudeau, an internationally regarded endocrinologist and professor at the University of Ottawa.
However, the function of Sg II (or SN) in the development of vertebrate embryos is not yet known.
researcher hu Wei and the Vance L. Trudeau team of the Chinese Academy of Sciences conducted a collaborative study on zebrafish, using gene editing technology to successfully obtain sgIIa-/-mutation, sgIIb-/mutation and sgIIa-//sgIIb-/-double-mutant zebrafish family.
studies have found that sgIIb-/-mutation sgIIa-///sgIIb-/-double-mutant zebrafish manifests itself as a central artery in the post-brain artery developmental defect in the embryonic stage.
using confocal delay photography and immunofluorestisation techniqueanalysis, it is learned that the defects of vascular development are caused by the migration and proliferation of endothelial cells, and the cell transplantation experiment sgIIb is not a spontaneous effect of post-cerebrovascular construction. further research
found that the post-brain venous differentiation in sgIIb-/-mutant embryos was not affected, and there was no significant change in the expression of the VEGF pathway and the Notch pathway key gene involved in vascular construction.
function of sgIb in neurovascular construction is mediated by MAPK and PI3K/Akt signaling pathways in endothelial cells.
the study for the first time, the study found sgII/SN's function in neurovascular development, suggesting that the new hormone SN is a neuropeptide that functions between both the neuroendocrine system and the vascular system.
results were recently published in Journal of Molecular Cell Biology in the form of a cover paper.
the study was conducted by Dr. Tao Binbin, a doctoral student, under the guidance of Hu Wei and Vance L. Trudeau.
research work was supported by the National Distinguished Youth Fund, the National Natural Science Foundation's Innovation Research Group Project and the University of Ottawa International Cooperation Project, and with the help of Jia Haibo, Professor of China Science and Technology University, Marie-Andr?e Akimenko, Professor of the University of Ottawa, and Xiong Jingwei, Professor of Peking University.
Source: Institute of Aquatic Biology.