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    Home > Biochemistry News > Biotechnology News > A new malaria vaccine vector-targeting the liver

    A new malaria vaccine vector-targeting the liver

    • Last Update: 2021-10-01
    • Source: Internet
    • Author: User
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    IVIS imaging results of mouse liver 8 days or 224 days after AAV-Luc administration showed that the liver luciferase activity induced by systemic administration of AAV8 was about 24-43 times that of intramuscular administration


    Malaria is still a deadly disease affecting people all over the world, especially in Africa


    Malaria vaccines are usually designed to generate an immune response to the P.


    The research team published early results using the adeno-associated virus serotype 1 (AAV1) vaccine backbone to target PfCSP


    The lead author of the study, Mohammad Shahnaij, explained: “AAV8 is a hepatotropic virus, which means it specifically targets the liver


    Researchers have created a vaccine that uses AAV8 as the backbone to express PfCSP


    Senior author Shigeto Yoshida explained: "IV injection allows the vaccine to enter mouse liver cells about 2.


    The team also tested the immune cell response after a single intravenous injection of AAV8-PfCSP


    Shahnaij said: "We observed a large number of cytotoxic T cells, especially effector memory T cells, in the liver of mice injected with intravenous AAV8-PfCSP


    These discoveries may completely change the field of anti-malaria treatment and may help save the lives of countless people living in malaria-ravaged regions of the world


    DOI

    10.


    Article title

    Liver-Directed AAV8 Booster Vaccine Expressing Plasmodium falciparum Antigen Following Adenovirus Vaccine Priming Elicits Sterile Protection in a Murine Model


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