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Malaria is still a deadly disease affecting people all over the world, especially in Africa
Malaria vaccines are usually designed to generate an immune response to the P.
The research team published early results using the adeno-associated virus serotype 1 (AAV1) vaccine backbone to target PfCSP
The lead author of the study, Mohammad Shahnaij, explained: “AAV8 is a hepatotropic virus, which means it specifically targets the liver
Researchers have created a vaccine that uses AAV8 as the backbone to express PfCSP
Senior author Shigeto Yoshida explained: "IV injection allows the vaccine to enter mouse liver cells about 2.
The team also tested the immune cell response after a single intravenous injection of AAV8-PfCSP
Shahnaij said: "We observed a large number of cytotoxic T cells, especially effector memory T cells, in the liver of mice injected with intravenous AAV8-PfCSP
These discoveries may completely change the field of anti-malaria treatment and may help save the lives of countless people living in malaria-ravaged regions of the world
DOI
10.
Article title
Liver-Directed AAV8 Booster Vaccine Expressing Plasmodium falciparum Antigen Following Adenovirus Vaccine Priming Elicits Sterile Protection in a Murine Model