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    Home > Food News > Food Articles > A new mechanism for plant regulation of endoplasmic reticulum stress-induced cell death revealed

    A new mechanism for plant regulation of endoplasmic reticulum stress-induced cell death revealed

    • Last Update: 2021-08-04
    • Source: Internet
    • Author: User
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    A new mechanism for plant regulation of endoplasmic reticulum stress-induced cell death revealed
    A new mechanism for plant regulation of endoplasmic reticulum stress-induced cell death revealed

    Under the guidance of researcher Hou Xingliang, post-doctoral researcher Yang Yuhua and associate researcher Liu Xu of the Agricultural and Biotechnology Research Center of South China Botanical Garden of the Chinese Academy of Sciences revealed a new mechanism of plant regulation of endoplasmic reticulum stress-induced cell death
    .


    Related research was recently published online in "Plant Physiology"


    The endoplasmic reticulum is an important place for protein synthesis and processing in cells
    .


    External environmental stress can cause unfolded or misfolded proteins to accumulate in the endoplasmic reticulum, thereby causing endoplasmic reticulum stress


    Researchers found that in response to stress, a pair of homologous proteins with DCD domains, NRP1 (asparagine-rich protein) and NRP2, act as pro-survival factors to inhibit plant cell death
    .


    In Arabidopsis thaliana, the simultaneous loss of NRP1 and NRP2 functions can lead to accelerated cell death, making the plant less resistant to endoplasmic reticulum stress inducer tunicamycin, and more sensitive to environmental stresses such as high salt and high temperature


    According to reports, the Arabidopsis bZIP60 gene encodes an important transcription factor that regulates UPR.
    Further studies have found that under endoplasmic reticulum stress, bZIP60 activates the expression of NRP1 by directly binding the UPR-related element UPRE-I in the NRP1 promoter.
    The transcription of NRP2 is not regulated by it
    .


    At the same time, bZIP60 regulates the expression of NRP1 and does not rely on the classic IRE1a/b-mediated mRNA splicing activation pathway


    The study revealed a new plant survival strategy, that is, in adversity, through different transcriptional regulation to activate the NRPs pathway to inhibit the transmission of cell death signals, so that plants increase the probability of survival under adverse conditions
    .


    (Source: China Science News, Zhu Hanbin, Zhou Fei)

    Related paper information: https://doi.


    https://doi.
    org/10.
    1093/plphys/kiab335
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