A new mechanism for regulating the development potential of embryonic stem cells.

U.S. researchers recently reported that they have found a way to make mouse embryonic stem cells acquire characteristics similar to those of fertilized eggs, and that modified embryonic stem cells can produce not only embryonic tissue, but also extraterrogenic tissue like fertilized eggs.
fertilized egg is considered an all-powerful stem cell with full developmental potential to differentiate all the cell types needed to produce embryonic development, including embryonic tissue and extraterrogenic tissue.
, including the placenta and the yolk sac, is essential for the exchange of nutrients between the fetus and the mother.
embryonic stem cells, taken from early embryos, are pluripotent stem cells with limited development potential and can form various cell types, but not produce extraterrogenic tissue.
team, led by He Lin, an associate professor of molecular and cell biology at the University of California, Berkeley, found that a micro-kerucleic acid called miR-34a in mouse embryonic stem cells braked to prevent embryonic stem cells from producing extraterrestopy tissue.
is a small molecule of KERNs that cannot be translated into proteins, but can regulate the expression of protein genes.
when the researchers removed miR-34a, embryonic stem cells were able to expand the potential of cell development to produce extraterrosional tissue cells, including the placenta and the yolk sac.
in the experiment, 20% of embryonic stem cells missing miR-34a showed an increase in this developmental potential.
the current limited research on the cell differentiation characteristics of the early stages of the fertilized egg, the researchers believe that this latest study could provide a new way to conduct this research.
results have been published online in the American journal Science.
, a Chinese-American scientist, believes the study has found a new mechanism for regulating the development potential of embryonic stem cells.
modified embryonic stem cells, although not the same as fertilized eggs, but in some aspects of the development of omnipotence and fertilized eggs have some similarities.
explained that the earliest cell differentiation in the development of fertilized eggs was to allow some cells to produce embryos and others to become placentals.
the lack of an experimental system for fertilizing egg culture has made such research difficult, and the scientific community has previously known little about the mechanisms that regulate cell differentiation.
, scientists have done a lot of research on how embryos develop, thanks in large part to in-body embryonic stem cell culture systems.
, scientists could use cell culture systems to study cell differentiation in the early stages of the development of fertilized eggs.
: Stem cells are a primitive and unsized type of multi-potential cell with the ability to replicate itself.
under certain conditions, it can differentiate into a variety of functional cells.
IPS is induced omnicnicnicnicnic stem cells, which refers to the introduction of certain transcription factors into animal or human somatic cells through gene transfedition technology, so that somatic cells directly reconstruct multi-potential cells called embryonic stem cell cells.
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