A new mechanism for the onion Burkehold bisignal receptor protein RpfR to regulate the viral force of pathogens.

Recently, South China Agricultural University subtropical agricultural biological resources protection and utilization of national key laboratory Professor Deng Music Group, for the first time revealed the onion Burkhold bacteria double signal receptor protein RpfR through the induction group sensing signal BDSF and intracellular c-di-GMP signal to regulate the pathogenic bacteria virus force of the new mechanism.
results were published in the Proceedings of the National Academy of Sciences.
BDSF is a group sensing signal that is widely present in pathogens and regulates important physiological functions, including viral forces.
the study revealed for the first time the molecular mechanisms of BDSF and c-di-GMP dual-signal molecular receptor protein RpfR to regulate downstream regulators.
in low bacterial cell density, the BDSF signal concentration is below the threshold, the phosphodiesterase in the EAL domain in RpfR remains low activity, the c-di-GMP molecule in the cell binds to the RpfR-GtrR complex, and inhibits the activity of the regulatory factor GtrR to regulate the target gene.
in high bacterial cell density, bacteria synthesize a large number of BDSF signals, BDSF signals combined with RpfR's PAS domain and enhance the activity of EAL degradation c-di-GMP, in intracellular low c-di-GMP conditions, BDSF-RpfR and GtrR form a complex, and promote gtrR regulatory target gene expression levels, and ultimately regulate the pathogenic pathogenic virus.
preliminary studies show that this kind of regulation mechanism is widely present in pathogens, and it is an important and widely existing regulatory mechanism.
.