A new mechanism of Alzheimer's "pathogenic protein" has been discovered

There are two main types of cells in the human brain, neuron cells and glial cells.
neuron cells are responsible for receiving stimuli, generating excitement and transmitting information in the form of nerve impulses, while the main function of glial cells is to support neurons through material metabolism.
lipoprotein E is secreted mainly by glial cells and then transmitted to neuron cells.
" this transport not only provides nutrients to neuron cells, we found that lipoprotein E can also inhibit the anabolic pathways of neuron cells themselves, thereby enhancing the neuron's information transmission function.
, " said Professor Liu Qiang.
Recently, their team used new methods of gene transcription and metalogic analysis to find that the lipoprotein variant E4 lost inhibitory regulation of neuron metabolism, preventing neuron cells from effectively activating the expression of learning and memory-related genes, leading to cognitive impairments such as learning and memory in Alzheimer's patients.
study sheds light on the new mechanisms by which lipoprotein E4 causes Alzheimer's disease, providing new directions and tools for future treatments.
, neurons, a well-known academic journal in the field of international neuroscience, published the results of the study.