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On July 22, 2021, the international academic journal Hepatology published online the research results of Yin Huiyong's research group at the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences entitled "ALDOB Depletion Promotes Hepatocellular Carcinogenesis through Activating Insulin Receptor Signaling and Lipogenesis"
Glycolipid metabolism is an important biological process for the body and cells to obtain energy and material sources
ALDOB is a member of the fructose 1,6-bisphosphate aldolase family.
In this study, researchers used proteomics and in vitro and in vivo immunoprecipitation experiments to find that ALDOB can directly bind to IR to inhibit IR autophosphorylation, resulting in a reduction in IR entering the nucleus and phosphorylated AKT levels, and reducing liver cell fatty acid de novo synthesis
In summary, this study clarified the new molecular mechanism of ALDOB regulating the insulin receptor signaling pathway
Liu Guijun, a doctoral student at the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, is the first author of the paper, and researcher Yin Huiyong and associate researcher Tao Yongzhen are the corresponding authors
Original link: https://aasldpubs.