A new strategy for treating HIV!

Recent popular reports from Yimaike ★ Interpretation of the challenges encountered in the pharmacology and pharmacology of cellular drugsNew observations from Yimai ★ Latest research results of Penn: A single injection of RNA drugs can improve vision for 15 monthsYimaihei Technology 2021 April 11/eMedClub News/--Recently, a research team from the University of California, Los Angeles published a research article in the journal PLOS Pathogens, showing that a CAR gene therapy is effective and long-lasting for HIV treatment Sex.

▲ Picture source: PLOS Pathogens AIDS is a disease caused by human immunodeficiency virus (HIV) infection.

After the HIV virus enters the body, it attacks the CD4+ T cells in the human immune system.
T cells are essential for the maintenance of the body’s immune system.
Therefore, when the human body’s T cells are affected by HIV and drop to a very low level, the immune system The body's defense and protection capabilities are basically lost, and it is difficult to deal with various pathogens and harmful stimuli that invade the body.
Without any treatment, AIDS patients will soon die of malignant tumors or infections.

Therefore, the researchers developed a CAR containing CD4 molecules to block the combination of HIV virus and CD4 molecules on normal T cells.
At the same time, the CAR was installed on genetically modified stem cells and then transplanted into patients.
Used to treat HIV.

▲ Full-length CD4 CAR (left), truncated CD4 CAR (right) Image source: PLOS Pathogens After the CAR gene therapy is infused into the body, white blood cells that specifically resist viral infections are formed, also known as CAR-T The CAR-T cell will block the binding of normal cells to HIV, and after the CAR binds to HIV, it will send out a signal to activate immune cells, which can specifically recognize and kill HIV-infected cells.

In previous studies, the University of California research team has suggested that this CAR gene therapy can continue to produce HIV-resistant cells for more than two years, but these cells are basically inactivated and will not be activated until they encounter HIV.

However, because it carries the CD4 molecule, there is also the possibility of CD4-CAR T being infected by HIV.
So in the latest study, the researchers deleted the domain of the CD4 molecule and developed a CAR that contains only a truncated form of the CD4 molecule.
, And then load it into hematopoietic stem cells.

In a mouse model study, the researchers found that this optimized CAR gene therapy can induce the human body’s immune response to HIV instead of passively waiting for the virus; it can also induce the production of a large number of memory T cells, which is more effective and faster.
Activate the immune system and respond to HIV.

Reference materials: 1.
https://journals.
plos.
org/plospathogens/article?id=10.
1371/journal.
ppat.
10094042.
https://newsroom.
ucla.
edu/releases/gene-therapy-car-t-cells -long-term-protection-hiv3.
https://newsroom.
ucla.
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