A new target for AD?

Alzheimer's disease is the most common neurodegenerative disease in the elderly, yet there are still no effective treatments to alter the course of the disease

In this study, Professor Gan's team used cell culture and mouse models to find that Tau tangles mainly drive the transformation of microglia into disease-related inflammatory phenotypes by activating the NF-κB signaling pathway in microglia

▲Illustration of this study (Image source: Reference [2])

In another mouse model of tauopathy, the researchers found that inhibiting the NF-κB signaling pathway in microglia shifted nearly all microglia from a disease-related inflammatory state to a more normal cell morphology and gene expression profile

"Our findings suggest that inhibiting overactive NF-κB signaling may be an effective therapeutic strategy for Alzheimer's disease and other tau-mediated neurodegenerative diseases,

References:

[1] Key signaling pathway in immune cells could be new Alzheimer's target.