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Computational biologist Dr Sonia Chothani, a Duke-NUS Cardiovascular and Metabolic Disease (CVMD) program researcher and lead author of the study, explained: "We have a large portion of the 2% of the genome that is known to encode proteins.
Scientists have been trying to identify smORFs and the small peptides they encode because disrupting these smORFs can lead to disease
"Many current datasets do not provide enough detailed information to identify smORFs in RNA," added Dr.
Publishing in the journal Molecular Cell, Chothani and her colleagues in Singapore, Germany, the UK and Australia describe an approach they developed to address these issues
Analysis of these data identified nearly 8,000 smORFs
"The genome is littered with smORFs," said Owen Rackham, the study's senior author and assistant professor from the CVMD program
Professor Patrick Casey, Senior Associate Dean of Duke-NUS, said: "As healthcare systems evolve to not only treat but prevent disease, identifying potential new targets for disease research and drug development can provide new opportunities for new Solutions open avenues
Sonia P.
