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Previous studies have shown that cancer cells in rapid division require higher levels of sugar than healthy cells.
this difference in sugar dependence is often used as the basis for therapy to target cancer cells.
in fact, treatment outcomes are often less than satisfactory.
not all cancer cells are sensitive to sugar, and even for sensitive cancer cells, the absence of sugar only slows the spread of cancer.
in short, the intrinsic mechanism of cancer cells' sensitivity to sugar defects is not well understood.
the team, led by Koji Itahana, an associate professor at Duke-NUS in Singapore, recently discovered for the first time a new type of cell death mechanism that explains the nature of cancer cells' death in the absence of sugar.
results were published in the latest issue of the journal Science Signalling.
we've long believed that sugar is the main source of nutrients for cancer cells, however, the authors found that for some types of cancer cells, the energy that sugar alone is not enough to sustain cell survival, meaning that the effect of sugar on cancer cell survival may not be more than just energy." After
, the authors found that sugar can channel key signals in cancer cell mediation, and that the lack of sugar can lead to changes in the potential difference on both sides of the cancer cell membrane, which in turn leads to a large amount of internal flow of calcium ions and cell death.
the authors suggest that this mechanism of sugar may help with future cancer treatments.
by combining to inhibit the supply of sugar and raising the level of calcium ions in cancer cells, the authors were able to successfully kill cancer cells without being affected.
, because specific cancer cells lose the ability to maintain intracellular sugar levels when the external sugar supply is insufficient, which explains why some cancers are not sensitive to sugar deficiency.
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