A novel mechanism of inter-organ long-distance communication: lung tissue extracellular vesicles regulate the chemotactic recruitment of bone marrow neutrophils in response to pathogenic microorganisms

On May 20 , 2022 , Professor Yin Yuxin's team from Peking University School of Basic Medicine published a research paper titled " E xtracellular vesicles from lung tissue drive bone marrow neutrophil recruitment in inflammation " in the Journal of Extracellular Vesicle.

EVs have been recognized in recent years as biomarkers for many diseases and as carriers of long-distance communication between cell.

The lung is an important respiratory hematopoietic org.

To solve the above problems, Yin Yuxin 's team successfully established an efficient method to collect high-quality EVs from human and mouse normal lung tissue.

Further studies confirmed the presence of dsDNA both inside and outside the membranes of lung EV.

Figure: Schematic diagram of the regulation of bone marrow neutrophil chemotaxis by lung EVs

In conclusion , this study established a high-quality separation and purification system for lung tissue EVs , which can accurately delineate their molecular composition and be used to study their distal regulatory functions in viv.

Liu Bowen, a doctoral student at Peking University School of Basic Medicine , and Jin Yuan, a postdoctoral fellow at Peking University School of Basic Medicine are the co-first authors of the paper, and Professor Yin Yuxin from the Institute of Systems Biomedicine, Peking University School of Basic Medicine is the corresponding auth.

Original link: https://d.

(Peking University School of Basic Medicine)