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    Home > Biochemistry News > Biotechnology News > A previously unknown cellular component: a new cellular component that is important for the sense of smell

    A previously unknown cellular component: a new cellular component that is important for the sense of smell

    • Last Update: 2023-02-03
    • Source: Internet
    • Author: User
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    This discovery was made possible by devvendra Kumar Maurya using a new technique called correlation microscopy, which combines electron microscopy and confocal microscopy so that the internal structure of cells and the location of different proteins can be imaged

    Source: Mattias Pettersson

    Researchers at Umeå University in Sweden have discovered a previously unknown cellular component, an organelle
    , in the neurons we use to sense odors.
    This finding may have implications for further research into impaired smell, a common symptom
    of COVID-19.

    Staffan Bohm, a professor in the Department of Molecular Biology, said: "The prerequisite for finding a cure for olfactory impairment is to first understand how smell works

    What the researchers found was a special organelle that resides inside nerve cells that had not been observed
    The newly discovered organelle is named Multivesicular Transducosome
    This discovery was made possible by the unique microscope infrastructure
    of Umeå University.

    Organelles are different "workstations" within cells that can be compared to different organs of the body, that is, different organelles have different functions
    in the cell.
    Most organelles are common in different types of cells, but there are also some organelles that have specific functions and only appear in certain types of
    Olfactory nerve cells have long protrusions, i.
    cilia, that reach into the nasal cavity and contain proteins that bind odorous substances, thus initiating nerve impulses to the brain
    The conversion of odors into nerve impulses is called transduction, while the newly discovered organelles contain only transducer proteins

    The role of transducers is to store and hold transduced proteins separated from each other until they are needed
    Under olfactory stimulation, the outer membrane of organelles ruptures, releasing conduction proteins that allow them to reach the cilia of neurons and smell is perceived

    The researchers also found that the transducer carries a protein called retinitis pigmentosa 2 (RP2), which regulates transduction
    in the eye's photoreceptor cells.
    If the RP2 gene is mutated, it can lead to mutations in retinitis pigmentosa in the eye disease, damaging the photosensitive cells
    of the eye.

    "One question that needs further study is whether this transducer plays a role in vision and whether it exists in
    brain neurons activated by neurotransmitters rather than light and smell.
    " If so, this finding could be even more significant," Bohm said

    The transducer was discovered
    when researcher Devendra Kumar Maurya used a new technique called correlation microscopy.
    This technique combines electron microscopy and confocal microscopy, so it is possible to simultaneously image the internal structure of the cell and the location of
    different proteins.
    Crucial to this discovery is this method, which enables the technique to be used to analyze intact neurons
    in tissue sections.

    Article A multivesicular body-like organelle mediates stimulus-regulated trafficking of olfactory ciliary transduction proteins

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