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Chemists have developed a leachable polyglycol acetic acid cellulose complex as a promising method for controlling the penetration pump tablets of catoprety porosity.
the purpose of this study is to develop a polyglycolated cellulose coating with leachable membranes made using controlled porosity permeability pump (CPOP) technology. Catoply has optimized the core tablets for CPOP applications
. In box-Behnken designs, cellulose acetate, polyethyl glycol and sorbitol are used as variables, while the percentage of kattopril's release is used as a response to the wrapping process.
the preparation is expressed by weight gain, leachable membrane thickness, content uniformity, drug release, pH, weight molar permeation pressure concentration effect of dissolved media, FTIR, and stability analysis for optimization purposes. The optimized formula is within the pharmacopeia range. The observed weight gain was 4.38-6.97% and the thickness of the leachable film was 1.24-1.47 mm. The content uniformity was 91.65-99.61%. PH 6.8 phosphate buffer showed 86.22-92.79% of drug release and first-stage release patterns. PH-dependent but permeable pressure-dependent drug release was observed.
-prepared CPOP tablets can be used for the controlled release
and the incompatibness between the ingredients of the preparation dosage form was not observed in the FTIR analysis. Six months of accelerated stability studies showed no significant changes in the dosage forms prepared.
conclusion is that prepared CPOP tablets can be used for the controlled release of catoply in patients with hypertension in order to maintain the desired concentration of the drug in the body over the required period of time.
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