Purpose: Hyperuricemia is a precursor to gout and is often present in other metabolic diseases promoted by dysbiosis of the microbiota
.
This study explored the relationship of gut microbiota to human hyperuricemia and serum urate levels
.
Purpose: Hyperuricemia is a precursor to gout and is often present in other metabolic diseases promoted by dysbiosis of the microbiota
.
This study explored the relationship of gut microbiota to human hyperuricemia and serum urate levels
.
Methods: Study participants were drawn from a community-based observational study, the Xiangya Osteoarthritis Study (Discovery Cohort)
.
Hyperuricemia was defined as serum uric acid levels >357 μM /L in women and >416 μM / L in men
.
Analysis of gut microbiota using 16S ribosomal RNA sequencing of stool samples .
This study examines the relationship between dysbiosis (i.
e.
, the richness, diversity, composition, and relative abundance of microbial communities) and predicts functional pathways leading to hyperuricemia and serum urate levels .
The investigators tested these associations in an independent observational study, the Step Study (validation cohort) .
.
Hyperuricemia was defined as serum uric acid levels >357 μM /L in women and >416 μM / L in men
.
Analysis of gut microbiota using 16S ribosomal RNA sequencing of stool samples .
This study examines the relationship between dysbiosis (i.
e.
, the richness, diversity, composition, and relative abundance of microbial communities) and predicts functional pathways leading to hyperuricemia and serum urate levels .
The investigators tested these associations in an independent observational study, the Step Study (validation cohort) .
RESULTS: The discovery cohort consisted of 1392 subjects from rural areas (mean age 61.
3 years, 57.
4% female, 17.
2% with hyperuricemia) .
Participants with hyperuricemia had reduced richness and diversity, altered microbiota composition, and lower relative abundance of Faecalis spp .
Predicted KEGG metabolic pathways, including amino acid and nucleotide metabolism, were significantly altered in hyperuricemic subjects compared with normouric acid subjects .
The richness, diversity and low relative abundance of Faecalicoccus in the gut microbiota were also associated with high levels of serum urate .
These findings were validated in a validation cohort of 480 participants .
3 years, 57.
4% female, 17.
2% with hyperuricemia)
.
Participants with hyperuricemia had reduced richness and diversity, altered microbiota composition, and lower relative abundance of Faecalis spp
.
Predicted KEGG metabolic pathways, including amino acid and nucleotide metabolism, were significantly altered in hyperuricemic subjects compared with normouric acid subjects .
The richness, diversity and low relative abundance of Faecalicoccus in the gut microbiota were also associated with high levels of serum urate .
These findings were validated in a validation cohort of 480 participants .
Conclusions: Intestinal dysbiosis is associated with elevated serum urate levels
.
This study examined the possibility that a dysbiosis of the microbiota may modulate serum urate levels
.
.
This study examined the possibility that a dysbiosis of the microbiota may modulate serum urate levels
.
Source: Wei, J.
, Zhang, Y.
, Dalbeth, N.
, Terkeltaub, R.
, Yang, T.
, Wang, Y.
, Yang, Z.
, Li, J.
, Wu, Z.
, Zeng, C .
and Lei, G.
(2022), Association Between Gut Microbiota and Elevated Serum Urate in Two Independent Cohorts.
Arthritis Rheumatol, 74: 682-691.
https://doi.
org/10.
1002/art.
42009
, Zhang, Y.
, Dalbeth, N.
, Terkeltaub, R.
, Yang, T.
, Wang, Y.
, Yang, Z.
, Li, J.
, Wu, Z.
, Zeng, C.
and Lei, G.
(2022), Association Between Gut Microbiota and Elevated Serum Urate in Two Independent Cohorts.
Arthritis Rheumatol, 74: 682-691.
https://doi.
org/10.
1002/art.
42009
Leave a comment here
