A&R: B cell depletion inhibits fibrosis by inhibiting the differentiation of pro-fibrotic macrophages in a mouse model of systemic sclerosis

Objective : systemic sclerosis (SSc) is an autoimmune immune disease, pathology mainly composed of three components: fibrosis, vascular disease, and autoimmune abnormalities
.

This study is to explore the effect of B cell depletion on SSc fibrosis and its mechanism

ObjectiveObjective : systemic sclerosis (SSc) is an autoimmune immune disease, pathology mainly composed of three components: fibrosis, vascular disease, and autoimmune abnormalities

Methods : Bleomycin-induced SSc (BLM-SSc) mice were treated with anti- CD20 antibody , and histopathological evaluation of skin and lung fibrosis was performed .

T cells and macrophages were co-cultured with B cells, and the influence of B cells on their differentiation was evaluated by flow cytometry .

MethodMethod : with an anti- CD20 antibody therapy bleomycin-induced SSc (BLM-SSc) in mice, and skin fibrosis and pulmonary histopathological evaluation

B cell depletion inhibited fibrosis in BLM-SSc mice

Conclusion These findings indicate that B cell depletion inhibits tissue fibrosis by inhibiting the differentiation of pro-fibrotic macrophages in BLM-SSc mice, providing a new theoretical basis for the treatment of B cell depletion in SSc .

Provenance

Numajiri, H.

, Kuzumi, A.
, Fukasawa, T.
, et al.
(2021), B Cell Depletion Inhibits Fibrosis via Suppression of Profibrotic Macrophage Differentiation in a Mouse Model of Systemic Sclerosis.
Arthritis Rheumatol, 73: 2086-2095.

Numajiri, H.
, Kuzumi, A.
, Fukasawa, T.
, et al.
(2021), B Cell Depletion Inhibits Fibrosis via Suppression of Profibrotic Macrophage Differentiation in a Mouse Model of Systemic Sclerosis.
Arthritis Rheumatol, 73: 2086-2095.
  https://doi.
org/10.
1002/art.
41798 https://doi.
org/10.
1002/art.
41798 Leave a message here