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A&R: CRTAC1 protein in plasma is associated with osteoarthritis and predicts whether joint replacement will be needed in the future: Large-scale proteomics scan in Iceland

 Last Update: 2021-12-25
 Source: Internet
 Author: User

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Purpose : Lack of biomarkers for the diagnosis and progression of osteoarthritis (OA) .
This study aims to identify OA cycle biomarkers that can predict the occurrence of disease and / or the progression of joint replacement .

ObjectiveObjective : lack for osteoarthritis (OA) diagnosis and progression biomarkers
.
This study aims to identify OA cycle biomarkers that can predict the occurrence of disease and / or the progression of joint replacement .

Method: Use the SomaScan platform (using the proximity extension method to measure protein to detect the specificity of SomaScan)

Method:Method: Use the SomaScan platform (using the proximity extension method to measure protein to detect the specificity of SomaScan)

Results:Results: Among the large number of plasma proteins evaluated, cartilage acid protein 1 (CRTAC1) has the strongest correlation with the two OA diagnoses ( odds ratio of knee OA , OR 1.

ConclusionConclusion : By no hypothetical method, the study plasma CRTAC1 identified as a new OA biomarker candidates, both with OA occurs about, but also to predict the progression of joint replacement

Source:

Styrkarsdottir, U.

, Lund, SH, Saevarsdottir, S.

Styrkarsdottir, U.

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