A&R: Endothelial Activation Antibodies in COVID-19 Patients

OBJECTIVE : Endothelial dysfunction is associated with widespread thrombo-inflammatory complications of COVID-19 , with venous thromboembolism being particularly pronounced ( 10-35% ) in severe COVID-19 , and autopsy specimen findings suggest it affects up to 60% of patients , and is associated with COVID-19- related mortalit.

OBJECTIVE : Endothelial dysfunction is associated with widespread thrombo-inflammatory complications of COVID-19 , with venous thromboembolism being particularly prevalent in severe COVID-19 ( 10-35% ), and autopsy specimen findings suggest that it affects up to 60% of patients and is associated with COVID-19- related mortalit.

Methods : Human endothelial cells were cultured in the presence of serum or plasma from 244 hospitalized patients with COVID - 19 and plasma from 100 non- COVID-19- related sepsis patient.

Methods Human endothelial cells were cultured in the presence of serum or plasma from 244 hospitalized patients with COVID - 19 and plasma from 100 non- COVID-19- related sepsis patient.

Results : Serum and plasma of COVID-19 patients increased the surface expression of cell adhesion molecul.

Results The serum and plasma of COVID-19 patients increased the surface expression of cell adhesion molecul.

Conclusions These data suggest for the first time that some COVID-19 patients may have multiple antibodies driving endothelial lesions, providing important context for the thromboinflammatory role of autoantibodies in severe COVID-1

Source: Shi,.

Source: Shi,.
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(2022), Endothelial Cell–Activating Antibodies in COVID-1 Arthritis Rheumatol, 74: 1132-113 https ://d.
org/11002/a.
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