A&R: Host genetics, not commensal microbiota, determines initial development of systemic autoimmune disease in BXD2 mice

Objective: To determine the extent to which the gut microbiome contributes to systemic autoimmunity in a mouse model of lupus

Objective: To determine the extent to which the gut microbiome contributes to systemic autoimmunity in a mouse model of lupus

We generated germ -free (GF) lupus-prone BXD2 mice that spontaneously produce germinal center (GC) and high titers of serum autoantibodies under normal conditions .

In 6 -month-old mice, GF status did not affect splenomegaly, GC B cells, age-related B cells, or serum autoantibody levels, with the exception of IgG anti-histone

The findings suggest a model in which genetics plays a leading role in determining the initial development of autoimmunity

Credit : Hong, H.

Hong, H.
, Alduraibi, F.
, Ponder, D.
, Duck, WL, Morrow, CD, Foote, JB, Schoeb, TR, Fatima, H.
, Elson, CO, III, Hsu, H.
-C.
and Mountz, JD (2022), Host Genetics But Not Commensal Microbiota Determines the Initial Development of Systemic Autoimmune Disease in BXD2 Mice.
Arthritis Rheumatol, 74: 634-640.
  https://doi.
org/10.
1002/art.
42008

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